<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:ffc3455b-541c-43d4-a53b-9ca1624f7e14,g:ccfe6bd9-1cf8-42d1-98de-94852a1d16aa-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CoverPage" xlink:type="simple" xlink:href="cfb-20200930.xsd#CoverPage"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CoverPage" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="cfb-20200930.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_abd15180-0ed8-4d57-bbd1-6fb4c597e0e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_41ae69eb-44d3-40fd-aedb-80fbb4c35c0b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_abd15180-0ed8-4d57-bbd1-6fb4c597e0e6" xlink:to="loc_us-gaap_PreferredStockValue_41ae69eb-44d3-40fd-aedb-80fbb4c35c0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_590354ea-850a-4f65-829f-4628796c181d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_abd15180-0ed8-4d57-bbd1-6fb4c597e0e6" xlink:to="loc_us-gaap_CommonStockValue_590354ea-850a-4f65-829f-4628796c181d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_302a93db-e5ea-4571-8051-1fa8665bb5d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_abd15180-0ed8-4d57-bbd1-6fb4c597e0e6" xlink:to="loc_us-gaap_AdditionalPaidInCapital_302a93db-e5ea-4571-8051-1fa8665bb5d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a81d5f5a-4d97-48b9-be70-bff1dcee51c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_abd15180-0ed8-4d57-bbd1-6fb4c597e0e6" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a81d5f5a-4d97-48b9-be70-bff1dcee51c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_0478f4b7-ea5b-49b8-90f1-5884840984fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_abd15180-0ed8-4d57-bbd1-6fb4c597e0e6" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_0478f4b7-ea5b-49b8-90f1-5884840984fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_f4256826-2aa9-46c5-a526-e11efc08975d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_11760068-f7e1-4b9c-b76b-05bee5d06a8c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_f4256826-2aa9-46c5-a526-e11efc08975d" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_11760068-f7e1-4b9c-b76b-05bee5d06a8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW_659dfc4d-6c08-4fba-b383-c3f3c22ddfa9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_f4256826-2aa9-46c5-a526-e11efc08975d" xlink:to="loc_us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW_659dfc4d-6c08-4fba-b383-c3f3c22ddfa9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_697960ef-08f3-466f-8a22-3ff4944b285c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_f4256826-2aa9-46c5-a526-e11efc08975d" xlink:to="loc_us-gaap_TimeDeposits_697960ef-08f3-466f-8a22-3ff4944b285c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_45c1143c-0597-4901-a552-a99e707c492a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_a357c4d5-237b-4ac1-acef-3871fd9a6224" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_45c1143c-0597-4901-a552-a99e707c492a" xlink:to="loc_us-gaap_Deposits_a357c4d5-237b-4ac1-acef-3871fd9a6224" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_318e12d6-dd67-4fc5-a2cc-8e63992dd3c4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_45c1143c-0597-4901-a552-a99e707c492a" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_318e12d6-dd67-4fc5-a2cc-8e63992dd3c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_8b658347-0a12-474f-b137-6afbe9ff00bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_45c1143c-0597-4901-a552-a99e707c492a" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_8b658347-0a12-474f-b137-6afbe9ff00bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherBorrowings_3c8e5334-e238-447f-a53e-df28f204651a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherBorrowings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_45c1143c-0597-4901-a552-a99e707c492a" xlink:to="loc_us-gaap_OtherBorrowings_3c8e5334-e238-447f-a53e-df28f204651a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_InterestPayableAndOtherLiabilities_78d9f863-1486-46f9-81ac-18ac42e529aa" xlink:href="cfb-20200930.xsd#cfb_InterestPayableAndOtherLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_45c1143c-0597-4901-a552-a99e707c492a" xlink:to="loc_cfb_InterestPayableAndOtherLiabilities_78d9f863-1486-46f9-81ac-18ac42e529aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4e6433e0-da08-46c3-a21f-844b0ba5893e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4e6433e0-da08-46c3-a21f-844b0ba5893e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_ShortTermInvestmentsTaxExempt_bfdf3e89-1925-495a-8c41-20ccd1a0a6bf" xlink:href="cfb-20200930.xsd#cfb_ShortTermInvestmentsTaxExempt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_cfb_ShortTermInvestmentsTaxExempt_bfdf3e89-1925-495a-8c41-20ccd1a0a6bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_ShortTermInvestmentsTaxable_271a41d3-3074-4e50-8d2d-103cfa957a41" xlink:href="cfb-20200930.xsd#cfb_ShortTermInvestmentsTaxable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_cfb_ShortTermInvestmentsTaxable_271a41d3-3074-4e50-8d2d-103cfa957a41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_ddace02f-afb2-47ab-841d-43b7f958ff0a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_NotesReceivableNet_ddace02f-afb2-47ab-841d-43b7f958ff0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_f1003283-2e1e-4d9d-8946-2322d8a65112" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_f1003283-2e1e-4d9d-8946-2322d8a65112" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRestricted_870abf27-8257-4ecd-ac45-a496fd746430" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiRestricted"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRestricted_870abf27-8257-4ecd-ac45-a496fd746430" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivable_ad45831c-021a-4769-bbde-c9308b178e4f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestReceivable"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_InterestReceivable_ad45831c-021a-4769-bbde-c9308b178e4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_RepossessedAssetsHeldForSale_7e359dda-7d2b-4fe2-914a-dd5487d6257a" xlink:href="cfb-20200930.xsd#cfb_RepossessedAssetsHeldForSale"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_cfb_RepossessedAssetsHeldForSale_7e359dda-7d2b-4fe2-914a-dd5487d6257a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_071d4f0e-4016-4307-844b-f939182c063f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_071d4f0e-4016-4307-844b-f939182c063f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_24c36a05-b171-4196-a70f-70b2d9af7f69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_24c36a05-b171-4196-a70f-70b2d9af7f69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsurance_0c517246-ead4-40bc-8385-bf90de36991b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BankOwnedLifeInsurance"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_BankOwnedLifeInsurance_0c517246-ead4-40bc-8385-bf90de36991b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_20b04b4a-ecce-4fb7-a486-2749bbbce638" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d05ec3f6-b5f7-47ff-9c7d-2490889360d3" xlink:to="loc_us-gaap_OtherAssets_20b04b4a-ecce-4fb7-a486-2749bbbce638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_61e60829-4e70-4a3d-beea-4af24ac0eec3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_b504b2ee-2149-4eac-90a0-77aba82e4598" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_61e60829-4e70-4a3d-beea-4af24ac0eec3" xlink:to="loc_us-gaap_Liabilities_b504b2ee-2149-4eac-90a0-77aba82e4598" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d8ccf3fa-b889-4015-b03e-75188d49b566" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_61e60829-4e70-4a3d-beea-4af24ac0eec3" xlink:to="loc_us-gaap_StockholdersEquity_d8ccf3fa-b889-4015-b03e-75188d49b566" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="cfb-20200930.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofIncomeUnaudited" xlink:type="simple" xlink:href="cfb-20200930.xsd#ConsolidatedStatementsofIncomeUnaudited"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofIncomeUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5dc6a47d-b6ac-4fca-968b-7b031a9fef8a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5dc6a47d-b6ac-4fca-968b-7b031a9fef8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnInvestments_03f832e7-ed6a-4404-91ee-487e60b52fe9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:to="loc_us-gaap_GainLossOnInvestments_03f832e7-ed6a-4404-91ee-487e60b52fe9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfLoansNet_732b7a1d-629f-4904-947b-25cd34966e9c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSalesOfLoansNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:to="loc_us-gaap_GainLossOnSalesOfLoansNet_732b7a1d-629f-4904-947b-25cd34966e9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_b1568593-6c1c-4db3-b60f-a2971feac2b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_b1568593-6c1c-4db3-b60f-a2971feac2b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_11357a63-18b9-4410-b4dd-85897c47a5ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_11357a63-18b9-4410-b4dd-85897c47a5ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_854d14f6-56f9-4633-b7fb-a27476a5ba63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_854d14f6-56f9-4633-b7fb-a27476a5ba63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_1600ca6f-a326-46bc-b21f-591f5c1f7e9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_07601837-a1f0-4564-80a6-5be20b092467" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_1600ca6f-a326-46bc-b21f-591f5c1f7e9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_9dc50d2f-a898-4bbc-834b-4ca835f01c1f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_de878396-9b3f-4411-8db0-4a5b0f404dcc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_9dc50d2f-a898-4bbc-834b-4ca835f01c1f" xlink:to="loc_us-gaap_InterestExpenseDeposits_de878396-9b3f-4411-8db0-4a5b0f404dcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_ac017622-23b7-4371-b322-2a674fe68e20" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_9dc50d2f-a898-4bbc-834b-4ca835f01c1f" xlink:to="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_ac017622-23b7-4371-b322-2a674fe68e20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesShortTerm_2e22982c-dc89-4e46-acca-44b35ec8efe4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesShortTerm"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_9dc50d2f-a898-4bbc-834b-4ca835f01c1f" xlink:to="loc_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesShortTerm_2e22982c-dc89-4e46-acca-44b35ec8efe4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOtherShortTermBorrowings_cf32d818-daa8-4661-9bb5-7aa38cfc1142" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseOtherShortTermBorrowings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_9dc50d2f-a898-4bbc-834b-4ca835f01c1f" xlink:to="loc_us-gaap_InterestExpenseOtherShortTermBorrowings_cf32d818-daa8-4661-9bb5-7aa38cfc1142" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_0233ee64-ca75-4c8e-86a5-afe7c2e36e75" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_bb46859d-d97c-49a7-9565-2a35ec22f380" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_0233ee64-ca75-4c8e-86a5-afe7c2e36e75" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_bb46859d-d97c-49a7-9565-2a35ec22f380" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_ee702a90-8586-4fb1-a234-a2e18dff9596" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_0233ee64-ca75-4c8e-86a5-afe7c2e36e75" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_ee702a90-8586-4fb1-a234-a2e18dff9596" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_4071c114-e264-42b5-985d-81534c52eb1f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_0233ee64-ca75-4c8e-86a5-afe7c2e36e75" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_4071c114-e264-42b5-985d-81534c52eb1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_3e983ebd-efea-4dc4-b808-f653d1d9a887" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeDepositsWithFinancialInstitutions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_0233ee64-ca75-4c8e-86a5-afe7c2e36e75" xlink:to="loc_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_3e983ebd-efea-4dc4-b808-f653d1d9a887" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendIncomeOperating_6697dd2d-be2f-42c2-9801-1b49182d0b9b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendIncomeOperating"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_0233ee64-ca75-4c8e-86a5-afe7c2e36e75" xlink:to="loc_us-gaap_DividendIncomeOperating_6697dd2d-be2f-42c2-9801-1b49182d0b9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_1cb67405-87da-4146-95de-c3d732474c69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_8578a05a-5a34-4b8b-8d38-bc4c29139e50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_1cb67405-87da-4146-95de-c3d732474c69" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_8578a05a-5a34-4b8b-8d38-bc4c29139e50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_cb9530aa-fca7-47e9-9460-e96c7ed0d7d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_1cb67405-87da-4146-95de-c3d732474c69" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_cb9530aa-fca7-47e9-9460-e96c7ed0d7d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_85bc2e51-c96b-4765-8d58-8cb72a07b940" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_952a51c1-6adc-4d68-b4b0-2a9496acfbe6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_85bc2e51-c96b-4765-8d58-8cb72a07b940" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_952a51c1-6adc-4d68-b4b0-2a9496acfbe6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_45c7ab2e-f8d2-46fb-8a7a-9dfd28081afb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_85bc2e51-c96b-4765-8d58-8cb72a07b940" xlink:to="loc_us-gaap_NoninterestIncome_45c7ab2e-f8d2-46fb-8a7a-9dfd28081afb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_12497ba3-5288-44c2-b83d-edcb86028ad8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_85bc2e51-c96b-4765-8d58-8cb72a07b940" xlink:to="loc_us-gaap_NoninterestExpense_12497ba3-5288-44c2-b83d-edcb86028ad8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_54a58457-0e43-49cf-a369-70535adae869" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_LaborAndRelatedExpense_54a58457-0e43-49cf-a369-70535adae869" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_b09f185c-51b6-4050-8fc0-6be8ade401fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_b09f185c-51b6-4050-8fc0-6be8ade401fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_38f53220-3e8c-41f1-b806-c2f660022781" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_OtherNoninterestExpense_38f53220-3e8c-41f1-b806-c2f660022781" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Communication_c9f5b699-86a6-4138-8523-49e1ced29de5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Communication"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_Communication_c9f5b699-86a6-4138-8523-49e1ced29de5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_2f1b780a-51df-43a2-926f-1afc9663d312" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_OccupancyNet_2f1b780a-51df-43a2-926f-1afc9663d312" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_c2d9450a-959b-42f5-a477-f5a58fa3b49e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalDepositInsuranceCorporationPremiumExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_c2d9450a-959b-42f5-a477-f5a58fa3b49e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_c4ef8bd4-4935-4343-a443-cfe91e5f809e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_c4ef8bd4-4935-4343-a443-cfe91e5f809e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_d7072684-e88c-470d-bc39-b5342ce85191" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProfessionalFees"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_ProfessionalFees_d7072684-e88c-470d-bc39-b5342ce85191" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeclosedRealEstateExpense_09bffd27-3410-4d34-a4e6-21220ed6aee1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeclosedRealEstateExpense"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_ForeclosedRealEstateExpense_09bffd27-3410-4d34-a4e6-21220ed6aee1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvertisingExpense_a3005e59-0c23-47a0-8679-0337f0b2f240" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvertisingExpense"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_7965f0c8-84af-4b25-be25-ddeb015fcb7b" xlink:to="loc_us-gaap_AdvertisingExpense_a3005e59-0c23-47a0-8679-0337f0b2f240" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_403cfb80-05b5-4e58-b67f-00dda89c8268" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_4b852d3d-9d1c-4b86-ab9b-5446fe418966" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_403cfb80-05b5-4e58-b67f-00dda89c8268" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_4b852d3d-9d1c-4b86-ab9b-5446fe418966" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_3c38cc0c-32a3-4192-8b55-d65f83daa619" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_403cfb80-05b5-4e58-b67f-00dda89c8268" xlink:to="loc_us-gaap_InterestExpense_3c38cc0c-32a3-4192-8b55-d65f83daa619" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_acb08748-d3f8-4311-8001-b7d2fcbc46f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_989853a3-1dbe-470a-bb4a-aeb7521b3bf2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_acb08748-d3f8-4311-8001-b7d2fcbc46f9" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_989853a3-1dbe-470a-bb4a-aeb7521b3bf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_64b802e6-9e94-41c4-b75f-58c42bed6fcc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_acb08748-d3f8-4311-8001-b7d2fcbc46f9" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_64b802e6-9e94-41c4-b75f-58c42bed6fcc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="simple" xlink:href="cfb-20200930.xsd#ConsolidatedStatementsofComprehensiveIncomeUnaudited"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_7423917b-89bb-4f8a-b4f2-484168846c65" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_8919de26-665a-49bd-8b1e-c2e4f3ae5e69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_7423917b-89bb-4f8a-b4f2-484168846c65" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_8919de26-665a-49bd-8b1e-c2e4f3ae5e69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_fcb98c82-327b-4275-a1b6-b42363979c6e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_7423917b-89bb-4f8a-b4f2-484168846c65" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_fcb98c82-327b-4275-a1b6-b42363979c6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_91f1a91c-6594-4683-ad2b-898437280318" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e5c34d5b-dd51-4876-94de-58011d278d5e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_91f1a91c-6594-4683-ad2b-898437280318" xlink:to="loc_us-gaap_NetIncomeLoss_e5c34d5b-dd51-4876-94de-58011d278d5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_a57b492f-87a6-450c-babc-90e98d6f5dc1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_91f1a91c-6594-4683-ad2b-898437280318" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_a57b492f-87a6-450c-babc-90e98d6f5dc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_4cbaab75-8c86-4c41-856c-0ce8b7cc28e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_d7d638ae-47b2-43d9-a59c-2a97c1d0f8ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_4cbaab75-8c86-4c41-856c-0ce8b7cc28e9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_d7d638ae-47b2-43d9-a59c-2a97c1d0f8ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_2c194b44-2306-41c9-a3c1-be42dc704390" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_4cbaab75-8c86-4c41-856c-0ce8b7cc28e9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_2c194b44-2306-41c9-a3c1-be42dc704390" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_311522fa-9248-42cd-8025-358e4b140975" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_473e8392-5bca-4940-9668-9b615b1baf73" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_311522fa-9248-42cd-8025-358e4b140975" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_473e8392-5bca-4940-9668-9b615b1baf73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_24312e01-2a8f-42f1-b82a-6adf8156d690" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_311522fa-9248-42cd-8025-358e4b140975" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_24312e01-2a8f-42f1-b82a-6adf8156d690" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofStockholdersEquityUnaudited" xlink:type="simple" xlink:href="cfb-20200930.xsd#ConsolidatedStatementsofStockholdersEquityUnaudited"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofStockholdersEquityUnaudited" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="cfb-20200930.xsd#ConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_42310ee1-9eda-443a-aeec-13d7a6c2a482" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_779bccaf-ffce-45f6-8b79-c2285efbad97" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_42310ee1-9eda-443a-aeec-13d7a6c2a482" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_779bccaf-ffce-45f6-8b79-c2285efbad97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f85c9fee-efb0-4399-b06f-63999569a854" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_42310ee1-9eda-443a-aeec-13d7a6c2a482" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f85c9fee-efb0-4399-b06f-63999569a854" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8ba414c3-3c74-4ac6-86cc-0fc2c92c25f8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_42310ee1-9eda-443a-aeec-13d7a6c2a482" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_8ba414c3-3c74-4ac6-86cc-0fc2c92c25f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_4af1f077-6b91-45ce-9030-40e453680eef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_4af1f077-6b91-45ce-9030-40e453680eef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_32ee4c8e-722e-4844-ab17-79240f300d3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_32ee4c8e-722e-4844-ab17-79240f300d3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_14cb10a1-9c74-4b17-96c9-1352fc53c270" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_14cb10a1-9c74-4b17-96c9-1352fc53c270" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_a8f7890d-bb4f-45e8-8fe3-f8e52fc43a27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_a8f7890d-bb4f-45e8-8fe3-f8e52fc43a27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_ccb8df26-1ac8-427e-b3d1-b0a8e9aafae8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_NetIncomeLoss_ccb8df26-1ac8-427e-b3d1-b0a8e9aafae8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_5c65954e-535c-40e8-af98-d1c5a4881284" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_5c65954e-535c-40e8-af98-d1c5a4881284" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_d33690fd-3096-4e57-95c8-2d0aa514b7d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_ShareBasedCompensation_d33690fd-3096-4e57-95c8-2d0aa514b7d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_64fad4af-3d68-4602-84c7-9effc7ffead1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_64fad4af-3d68-4602-84c7-9effc7ffead1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetImpairmentCharges_da2b1d8d-44c9-4c70-ac05-1fcd3d73398e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetImpairmentCharges"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_OtherAssetImpairmentCharges_da2b1d8d-44c9-4c70-ac05-1fcd3d73398e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_08bd53b6-cc07-4fce-92ed-3387fe1296aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_08bd53b6-cc07-4fce-92ed-3387fe1296aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_13afdd07-6198-4adc-af33-55c7110ba3c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_13afdd07-6198-4adc-af33-55c7110ba3c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_83c668f7-2715-4e70-9efb-86e37899dc51" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b5d056a8-12a6-4d5b-9459-c96b2770d997" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_83c668f7-2715-4e70-9efb-86e37899dc51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromLoansReceivable_e0309561-c1bd-49e5-af1d-a19d20f7777c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForProceedsFromLoansReceivable"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:to="loc_us-gaap_PaymentsForProceedsFromLoansReceivable_e0309561-c1bd-49e5-af1d-a19d20f7777c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_5bae183f-5287-4a66-b461-ae1ead07f171" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_5bae183f-5287-4a66-b461-ae1ead07f171" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_25b5aa0e-3a06-48ed-af00-24b824e64518" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_25b5aa0e-3a06-48ed-af00-24b824e64518" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_bfae60d5-1243-4a55-95cc-ca19cf74571e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_bfae60d5-1243-4a55-95cc-ca19cf74571e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireRestrictedInvestments_919e1c5c-1301-4d54-85f8-473f343fd13e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireRestrictedInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:to="loc_us-gaap_PaymentsToAcquireRestrictedInvestments_919e1c5c-1301-4d54-85f8-473f343fd13e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_55cfbfc8-75a2-48d3-80bd-364070caca25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_55cfbfc8-75a2-48d3-80bd-364070caca25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_2d118a00-b4b8-4394-b81d-825087ba7e62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_660614f2-4234-450b-91f0-b1909e466a78" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_2d118a00-b4b8-4394-b81d-825087ba7e62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_IncreaseDecreaseInDemandDepositsSavingsNOWAndMoneyMarketAccounts_ee811195-2df4-4715-93d5-7476f02a34cc" xlink:href="cfb-20200930.xsd#cfb_IncreaseDecreaseInDemandDepositsSavingsNOWAndMoneyMarketAccounts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_cfb_IncreaseDecreaseInDemandDepositsSavingsNOWAndMoneyMarketAccounts_ee811195-2df4-4715-93d5-7476f02a34cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTimeDeposits_2ad16b95-0347-401e-9f7b-dc024cf9d479" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInTimeDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_IncreaseDecreaseInTimeDeposits_2ad16b95-0347-401e-9f7b-dc024cf9d479" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_e6d1b05d-9ffe-4ca7-87a8-6de0ed690dd8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_e6d1b05d-9ffe-4ca7-87a8-6de0ed690dd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromFederalHomeLoanBankBorrowings_7864428c-154e-4b9f-a172-c0ce0157e68e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromFederalHomeLoanBankBorrowings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_ProceedsFromFederalHomeLoanBankBorrowings_7864428c-154e-4b9f-a172-c0ce0157e68e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_cd7cb5ce-8884-474c-b0a8-071185c76c46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_cd7cb5ce-8884-474c-b0a8-071185c76c46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_ff79d90a-8aaa-416e-80fb-728bcd4ae3ba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_ff79d90a-8aaa-416e-80fb-728bcd4ae3ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_b33646f9-7123-4edd-89ec-c600712a1536" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_b33646f9-7123-4edd-89ec-c600712a1536" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4188b632-5c5e-4799-874b-3c22549500de" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4188b632-5c5e-4799-874b-3c22549500de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_84794fe2-2942-4e42-9350-e13aadfa6a4a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_84794fe2-2942-4e42-9350-e13aadfa6a4a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_IncreaseDecreaseInFederalFundsSoldFinancingActivities_04c7d56c-3842-4e3b-944b-769ce7e32929" xlink:href="cfb-20200930.xsd#cfb_IncreaseDecreaseInFederalFundsSoldFinancingActivities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_cfb_IncreaseDecreaseInFederalFundsSoldFinancingActivities_04c7d56c-3842-4e3b-944b-769ce7e32929" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_IncreaseDecreaseInEmployeeReceivables_1301f50c-9416-430a-8b01-be3e2f47b459" xlink:href="cfb-20200930.xsd#cfb_IncreaseDecreaseInEmployeeReceivables"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4ddf014a-f180-46ab-a3de-e604e6f4a64b" xlink:to="loc_cfb_IncreaseDecreaseInEmployeeReceivables_1301f50c-9416-430a-8b01-be3e2f47b459" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="cfb-20200930.xsd#NatureofOperationsandSummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="cfb-20200930.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EarningsPerShare" xlink:type="simple" xlink:href="cfb-20200930.xsd#EarningsPerShare"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EarningsPerShare" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EarningsPerShareTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#EarningsPerShareTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EarningsPerShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_79fabd25-7d82-4f8e-8a0c-e1c29b082c48" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f4f65830-2f1b-4106-a812-f945069c28cc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_79fabd25-7d82-4f8e-8a0c-e1c29b082c48" xlink:to="loc_us-gaap_NetIncomeLoss_f4f65830-2f1b-4106-a812-f945069c28cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsAndOtherAdjustments_5a34fb04-a5e4-4628-9020-77dc6acc612b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockDividendsAndOtherAdjustments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_79fabd25-7d82-4f8e-8a0c-e1c29b082c48" xlink:to="loc_us-gaap_PreferredStockDividendsAndOtherAdjustments_5a34fb04-a5e4-4628-9020-77dc6acc612b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_81dd9470-27d6-43e5-b213-8b75ebd39626" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_00a93b2d-02b5-4095-8b25-9fac934a01c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_81dd9470-27d6-43e5-b213-8b75ebd39626" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_00a93b2d-02b5-4095-8b25-9fac934a01c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1979e9f1-c9ab-4032-bed3-54b56e21f8a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_81dd9470-27d6-43e5-b213-8b75ebd39626" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_1979e9f1-c9ab-4032-bed3-54b56e21f8a3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/Securities" xlink:type="simple" xlink:href="cfb-20200930.xsd#Securities"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/Securities" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#SecuritiesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValueofSecuritiesDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#SecuritiesAmortizedCostandFairValueofSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValueofSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCost_333361fa-af4a-4f2f-a7fd-eaf220eb6427" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_c3e73e8b-2e02-483d-bbb6-54b3ebd39b38" xlink:href="cfb-20200930.xsd#cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedGain"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiCost_333361fa-af4a-4f2f-a7fd-eaf220eb6427" xlink:to="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_c3e73e8b-2e02-483d-bbb6-54b3ebd39b38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_258a73ec-81a5-41e3-9ef3-0eb076fec500" xlink:href="cfb-20200930.xsd#cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiCost_333361fa-af4a-4f2f-a7fd-eaf220eb6427" xlink:to="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_258a73ec-81a5-41e3-9ef3-0eb076fec500" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_82962aff-f17b-4b99-a69d-fbfe71045a97" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiCost_333361fa-af4a-4f2f-a7fd-eaf220eb6427" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_82962aff-f17b-4b99-a69d-fbfe71045a97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_f46fc95a-a839-4897-85d2-11dfd6f4a71d" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_a6a792ba-1b47-4ab8-acd2-12472c007701" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_f46fc95a-a839-4897-85d2-11dfd6f4a71d" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_a6a792ba-1b47-4ab8-acd2-12472c007701" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_c182138a-b786-4496-b2a6-ac58a055b934" xlink:href="cfb-20200930.xsd#cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_f46fc95a-a839-4897-85d2-11dfd6f4a71d" xlink:to="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_c182138a-b786-4496-b2a6-ac58a055b934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_727e6470-9a6a-4517-9fcd-2c7ee9bba354" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3e51cbe7-c7c8-41e2-ac6d-3ef68aacd760" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_727e6470-9a6a-4517-9fcd-2c7ee9bba354" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3e51cbe7-c7c8-41e2-ac6d-3ef68aacd760" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_a345b9e0-b54e-499f-9920-df9485b928dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_727e6470-9a6a-4517-9fcd-2c7ee9bba354" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_a345b9e0-b54e-499f-9920-df9485b928dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_778df270-ba42-4f30-ae39-d7254afdda89" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_727e6470-9a6a-4517-9fcd-2c7ee9bba354" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_778df270-ba42-4f30-ae39-d7254afdda89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost_85a14c1f-e595-4e3c-924a-9648299a9fcb" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_8d40e563-4c8c-4d8c-959c-4302fa8ae88e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost_85a14c1f-e595-4e3c-924a-9648299a9fcb" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_8d40e563-4c8c-4d8c-959c-4302fa8ae88e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCost_15aca115-767e-4a21-9c76-a17317d0bedf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost_85a14c1f-e595-4e3c-924a-9648299a9fcb" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCost_15aca115-767e-4a21-9c76-a17317d0bedf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI_3ff719ab-f848-4fd6-a9d6-2f9d41d61269" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4ff30532-426e-4fb9-beb3-a96a10ce2fb9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI_3ff719ab-f848-4fd6-a9d6-2f9d41d61269" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4ff30532-426e-4fb9-beb3-a96a10ce2fb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_9c7b0756-1660-4a4c-b751-2f5060a24ad6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI_3ff719ab-f848-4fd6-a9d6-2f9d41d61269" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_9c7b0756-1660-4a4c-b751-2f5060a24ad6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_1900dee2-d523-4325-bf40-819167e7de34" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedGain"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_0302eb1e-c2b3-4678-ae15-700d9322b633" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_1900dee2-d523-4325-bf40-819167e7de34" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_0302eb1e-c2b3-4678-ae15-700d9322b633" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_c1148e91-f19d-4583-b51c-b14370ca087c" xlink:href="cfb-20200930.xsd#cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedGain"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_1900dee2-d523-4325-bf40-819167e7de34" xlink:to="loc_cfb_EquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_c1148e91-f19d-4583-b51c-b14370ca087c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValueofSecuritiesDetails_1" xlink:type="simple" xlink:href="cfb-20200930.xsd#SecuritiesAmortizedCostandFairValueofSecuritiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValueofSecuritiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost_37950881-03bf-4e60-b05d-815a10a94c3f" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_73f230aa-4303-4cc9-89c6-d192e40693fb" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedGain"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost_37950881-03bf-4e60-b05d-815a10a94c3f" xlink:to="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedGain_73f230aa-4303-4cc9-89c6-d192e40693fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_72317d79-8986-464e-81f0-bb6b29dad019" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost_37950881-03bf-4e60-b05d-815a10a94c3f" xlink:to="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAccumulatedGrossUnrealizedLoss_72317d79-8986-464e-81f0-bb6b29dad019" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI_d3df3be8-e4ce-4dfe-b486-586c0b9279d8" xlink:href="cfb-20200930.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNIAmortizedCost_37950881-03bf-4e60-b05d-815a10a94c3f" xlink:to="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI_d3df3be8-e4ce-4dfe-b486-586c0b9279d8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValuebyMaturityDateDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#SecuritiesAmortizedCostandFairValuebyMaturityDateDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValuebyMaturityDateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_10921ca6-0673-425a-a6ca-0b678a28a9c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_c218b718-ff2c-4970-be0f-6c11175535ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_10921ca6-0673-425a-a6ca-0b678a28a9c5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_c218b718-ff2c-4970-be0f-6c11175535ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_c8917323-d942-465e-a9a8-39ea8d29fa7f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_10921ca6-0673-425a-a6ca-0b678a28a9c5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_c8917323-d942-465e-a9a8-39ea8d29fa7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_f6dd693e-a41f-49f8-9396-9114a25d9025" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_10921ca6-0673-425a-a6ca-0b678a28a9c5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_f6dd693e-a41f-49f8-9396-9114a25d9025" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_1d441fbc-e8da-42fa-be31-b0588da10d71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_10921ca6-0673-425a-a6ca-0b678a28a9c5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_1d441fbc-e8da-42fa-be31-b0588da10d71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d092413d-b803-4de9-8840-81ed16ac6261" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_49b6cc57-4e77-4973-94d3-06305df133d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d092413d-b803-4de9-8840-81ed16ac6261" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_49b6cc57-4e77-4973-94d3-06305df133d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_4494b143-2099-42ea-93e9-cc386d56e165" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d092413d-b803-4de9-8840-81ed16ac6261" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_4494b143-2099-42ea-93e9-cc386d56e165" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_a3a6db4a-ab67-4270-a1d2-15f447dc0a79" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d092413d-b803-4de9-8840-81ed16ac6261" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_a3a6db4a-ab67-4270-a1d2-15f447dc0a79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_45954b3b-568a-4dab-9500-cd2231c6b2c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d092413d-b803-4de9-8840-81ed16ac6261" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_45954b3b-568a-4dab-9500-cd2231c6b2c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesUnrealizedLossesDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#SecuritiesUnrealizedLossesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesUnrealizedLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_1785d713-0fa8-4183-abf2-9f1583352354" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_1ef0a278-fbdf-47c2-96d2-68917fa88d22" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_1785d713-0fa8-4183-abf2-9f1583352354" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_1ef0a278-fbdf-47c2-96d2-68917fa88d22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_a28a5e58-42b5-47bc-9966-5976f010d06b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_1785d713-0fa8-4183-abf2-9f1583352354" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_a28a5e58-42b5-47bc-9966-5976f010d06b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_dfaf4828-05e6-49a4-b64a-82998bee3700" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions_03536946-be0e-4282-adca-20f829d27f14" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_dfaf4828-05e6-49a4-b64a-82998bee3700" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions_03536946-be0e-4282-adca-20f829d27f14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_28dee65a-d294-40af-8750-9e1b00901da7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_dfaf4828-05e6-49a4-b64a-82998bee3700" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_28dee65a-d294-40af-8750-9e1b00901da7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_1b80fb11-50bb-43e3-9261-4ca692f0ed39" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_e490a8ce-1d13-45ed-b776-47e46eedcf5a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_1b80fb11-50bb-43e3-9261-4ca692f0ed39" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_e490a8ce-1d13-45ed-b776-47e46eedcf5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_2d290c52-727a-4410-a12a-c5cbe7d693c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_1b80fb11-50bb-43e3-9261-4ca692f0ed39" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_2d290c52-727a-4410-a12a-c5cbe7d693c7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#SecuritiesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLL" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLL"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLL" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLCategoryofLoansDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLCategoryofLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLCategoryofLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_47fca38a-793f-4593-8fcc-8e9121a66afe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_d7756e81-34c1-460b-aa70-0e414543947b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_47fca38a-793f-4593-8fcc-8e9121a66afe" xlink:to="loc_us-gaap_NotesReceivableGross_d7756e81-34c1-460b-aa70-0e414543947b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_9d309d62-feb3-4f11-a874-c6fdf3352356" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_47fca38a-793f-4593-8fcc-8e9121a66afe" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_9d309d62-feb3-4f11-a874-c6fdf3352356" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableDeferredIncome_92cea0d9-304a-4374-b26b-770d3acf0705" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableDeferredIncome"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_47fca38a-793f-4593-8fcc-8e9121a66afe" xlink:to="loc_us-gaap_FinancingReceivableDeferredIncome_92cea0d9-304a-4374-b26b-770d3acf0705" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLAllowanceforLoanLossesDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLAllowanceforLoanLossesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLAllowanceforLoanLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_e33d7977-ed5f-4140-ad20-4ae94f73d7ae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment_6d2e239c-4e27-4fef-8523-f3afb1aa074f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_e33d7977-ed5f-4140-ad20-4ae94f73d7ae" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment_6d2e239c-4e27-4fef-8523-f3afb1aa074f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1_6ee0cfa5-dec6-4340-a0f1-9bbb51d07f4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_e33d7977-ed5f-4140-ad20-4ae94f73d7ae" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1_6ee0cfa5-dec6-4340-a0f1-9bbb51d07f4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_f7e8c9b5-6f30-4227-8804-c6f8bd61498a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment_4f54c8cc-606d-4f5c-87c5-795f0789a0ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f7e8c9b5-6f30-4227-8804-c6f8bd61498a" xlink:to="loc_us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment_4f54c8cc-606d-4f5c-87c5-795f0789a0ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment_dd34216b-557a-4896-bd56-087d6e43af8c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f7e8c9b5-6f30-4227-8804-c6f8bd61498a" xlink:to="loc_us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment_dd34216b-557a-4896-bd56-087d6e43af8c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLInternalRiskRatingsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLInternalRiskRatingsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLInternalRiskRatingsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLLoanAgingAnalysisDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLLoanAgingAnalysisDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLLoanAgingAnalysisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_d50e546f-64b8-4ab3-a0ed-ed9c7475f877" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDue_1425f9c2-4beb-4cd8-8d2e-409171085440" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_d50e546f-64b8-4ab3-a0ed-ed9c7475f877" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDue_1425f9c2-4beb-4cd8-8d2e-409171085440" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentCurrent_15effb67-d607-4c3c-a2db-fc94488fda45" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_d50e546f-64b8-4ab3-a0ed-ed9c7475f877" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentCurrent_15effb67-d607-4c3c-a2db-fc94488fda45" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLImpairedLoansDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLImpairedLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLImpairedLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableRecordedInvestment_b1c0d322-0dca-4af7-b846-522c1f07c5b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableRecordedInvestment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_a0558e49-dd55-4426-87f8-ce55a4f0f51f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableRecordedInvestment_b1c0d322-0dca-4af7-b846-522c1f07c5b3" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_a0558e49-dd55-4426-87f8-ce55a4f0f51f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_aa344bbd-f0be-4ab3-a7dc-598e5cdb5967" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableRecordedInvestment_b1c0d322-0dca-4af7-b846-522c1f07c5b3" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_aa344bbd-f0be-4ab3-a7dc-598e5cdb5967" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_557e3935-6dae-47d0-beea-0719dc3196cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_06a3da33-5512-46c9-bf08-c34ab5eef2c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_557e3935-6dae-47d0-beea-0719dc3196cb" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_06a3da33-5512-46c9-bf08-c34ab5eef2c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_c7f8c5d0-ff2a-4608-940f-3cb4ce9735e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_557e3935-6dae-47d0-beea-0719dc3196cb" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_c7f8c5d0-ff2a-4608-940f-3cb4ce9735e4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLImpairedLoanInterestIncomeandAverageImpairedLoansDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLImpairedLoanInterestIncomeandAverageImpairedLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLImpairedLoanInterestIncomeandAverageImpairedLoansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLNonAccrualLoansDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLNonAccrualLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLNonAccrualLoansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLTroubledDebtRestructuringLoansDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#LoansandAllowanceforLoanLossesALLLTroubledDebtRestructuringLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLossesALLLTroubledDebtRestructuringLoansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedging" xlink:type="simple" xlink:href="cfb-20200930.xsd#DerivativesandHedging"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedging" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#DerivativesandHedgingTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingOutstandingDerivativesDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#DerivativesandHedgingOutstandingDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingOutstandingDerivativesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingFairValueofDerivativesDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#DerivativesandHedgingFairValueofDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingFairValueofDerivativesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssets" xlink:type="simple" xlink:href="cfb-20200930.xsd#GoodwillandOtherIntangibleAssets"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssets" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssetsTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#GoodwillandOtherIntangibleAssetsTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssetsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssetsNarrativeDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#GoodwillandOtherIntangibleAssetsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssetsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandOtherIntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_34cd1279-27ed-4df2-bb76-c62dd3b55f65" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetImpairment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_eb0c7751-1b91-45ed-88a1-729baadb0a57" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_34cd1279-27ed-4df2-bb76-c62dd3b55f65" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_eb0c7751-1b91-45ed-88a1-729baadb0a57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_99e76c8f-8ee7-4664-9e6a-a8ce70712a2f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetImpairment_34cd1279-27ed-4df2-bb76-c62dd3b55f65" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_99e76c8f-8ee7-4664-9e6a-a8ce70712a2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ce555553-b72d-4ebf-b684-b1ef9640434b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_96e0229a-ff94-4349-b20d-0e527b0d266d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ce555553-b72d-4ebf-b684-b1ef9640434b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_96e0229a-ff94-4349-b20d-0e527b0d266d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_057e651c-9f24-44ea-890e-e48c2f6e6f7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ce555553-b72d-4ebf-b684-b1ef9640434b" xlink:to="loc_us-gaap_Goodwill_057e651c-9f24-44ea-890e-e48c2f6e6f7a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/TimeDepositsandBorrowings" xlink:type="simple" xlink:href="cfb-20200930.xsd#TimeDepositsandBorrowings"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/TimeDepositsandBorrowings" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/TimeDepositsandBorrowingsTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#TimeDepositsandBorrowingsTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/TimeDepositsandBorrowingsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/TimeDepositsandBorrowingsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#TimeDepositsandBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/TimeDepositsandBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_d3335bc2-5176-4fe3-813d-e72ce7de38e8" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_8fd03a45-24b6-40a8-8ded-ac655d983651" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_d3335bc2-5176-4fe3-813d-e72ce7de38e8" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_8fd03a45-24b6-40a8-8ded-ac655d983651" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_08d3483c-6859-4677-ae61-fc7c82b63e71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_d3335bc2-5176-4fe3-813d-e72ce7de38e8" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_08d3483c-6859-4677-ae61-fc7c82b63e71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_039b54ba-7737-482d-aa10-4eb952ecb479" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_d3335bc2-5176-4fe3-813d-e72ce7de38e8" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_039b54ba-7737-482d-aa10-4eb952ecb479" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_c13da2bb-3f36-4ca3-9d1e-96db68415fc3" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_ca7d76eb-d24b-4308-864b-7545b3816ed8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_c13da2bb-3f36-4ca3-9d1e-96db68415fc3" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_ca7d76eb-d24b-4308-864b-7545b3816ed8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_7f30bae3-661d-4499-891a-07f9cf02e136" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_c13da2bb-3f36-4ca3-9d1e-96db68415fc3" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_7f30bae3-661d-4499-891a-07f9cf02e136" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_acfc991f-7870-4b76-8a11-5ffb63ee4866" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_c13da2bb-3f36-4ca3-9d1e-96db68415fc3" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_acfc991f-7870-4b76-8a11-5ffb63ee4866" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowings_488fd498-8bea-4d93-a0a9-c25bc198f10a" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowings"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_5486ab84-cd41-49b9-86dd-88bf78a43359" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_488fd498-8bea-4d93-a0a9-c25bc198f10a" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_5486ab84-cd41-49b9-86dd-88bf78a43359" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_7753d071-2143-4afa-8a70-ba8c7795b3fe" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_488fd498-8bea-4d93-a0a9-c25bc198f10a" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_7753d071-2143-4afa-8a70-ba8c7795b3fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_6c759e9e-9b9c-41f0-a460-ff9916f7bffd" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_488fd498-8bea-4d93-a0a9-c25bc198f10a" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_6c759e9e-9b9c-41f0-a460-ff9916f7bffd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_0890f5aa-4515-4185-9818-79f6b4bb361a" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_488fd498-8bea-4d93-a0a9-c25bc198f10a" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_0890f5aa-4515-4185-9818-79f6b4bb361a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_c66f5493-fba5-415a-9e1d-0fb135c7675d" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_488fd498-8bea-4d93-a0a9-c25bc198f10a" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_c66f5493-fba5-415a-9e1d-0fb135c7675d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_ba1112e8-bf95-457e-81cd-07317d8087e2" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_488fd498-8bea-4d93-a0a9-c25bc198f10a" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_ba1112e8-bf95-457e-81cd-07317d8087e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_a50e427e-68ec-452d-ab2a-83f6e6b90314" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_7f677cbf-0980-4fbd-8533-592ac0913db9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesAfterRollingYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_a50e427e-68ec-452d-ab2a-83f6e6b90314" xlink:to="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_7f677cbf-0980-4fbd-8533-592ac0913db9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_73c67542-e65e-4bdc-bd7a-c4b8e6dd67ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_a50e427e-68ec-452d-ab2a-83f6e6b90314" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_73c67542-e65e-4bdc-bd7a-c4b8e6dd67ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_26256321-9575-4a8e-a2db-78cc379651cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_a50e427e-68ec-452d-ab2a-83f6e6b90314" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_26256321-9575-4a8e-a2db-78cc379651cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_a399082f-ab9c-4aa4-849d-2e400dd7e531" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_f65c5950-df92-43c7-a9be-721bc6d119a0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_a399082f-ab9c-4aa4-849d-2e400dd7e531" xlink:to="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_f65c5950-df92-43c7-a9be-721bc6d119a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_0883e6a6-14da-427f-bf35-cab4b4646a27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_a399082f-ab9c-4aa4-849d-2e400dd7e531" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_0883e6a6-14da-427f-bf35-cab4b4646a27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_e6450426-e6d2-44d8-998b-79f5e28bce4a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_a399082f-ab9c-4aa4-849d-2e400dd7e531" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_e6450426-e6d2-44d8-998b-79f5e28bce4a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_ee3ef5a6-991e-4c8f-9021-49fd4c6494c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_a399082f-ab9c-4aa4-849d-2e400dd7e531" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_ee3ef5a6-991e-4c8f-9021-49fd4c6494c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_3cf64311-af3b-4af2-adbb-6357d47d2386" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_a5909aec-1e7a-43e2-a6bc-1af2f0720958" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_3cf64311-af3b-4af2-adbb-6357d47d2386" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_a5909aec-1e7a-43e2-a6bc-1af2f0720958" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_3f786a99-fb3a-4dcf-88ff-2538aa814357" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_3cf64311-af3b-4af2-adbb-6357d47d2386" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_3f786a99-fb3a-4dcf-88ff-2538aa814357" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_d387d111-90ac-427e-a520-d8bf80fb8f1e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_3cf64311-af3b-4af2-adbb-6357d47d2386" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_d387d111-90ac-427e-a520-d8bf80fb8f1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_52b6c1ca-e965-4a57-8577-a72807b8fbff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_d22e2843-5ebe-4ff8-bf43-91a29325b863" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_52b6c1ca-e965-4a57-8577-a72807b8fbff" xlink:to="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_d22e2843-5ebe-4ff8-bf43-91a29325b863" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_eeb134d3-103c-4f3b-95f0-534ce355d621" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_52b6c1ca-e965-4a57-8577-a72807b8fbff" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_eeb134d3-103c-4f3b-95f0-534ce355d621" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_19a87dbc-e1d6-462b-b276-ec0185f4810d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_52b6c1ca-e965-4a57-8577-a72807b8fbff" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_19a87dbc-e1d6-462b-b276-ec0185f4810d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_87b04250-5bbf-4dae-9de1-75e337140b34" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_52b6c1ca-e965-4a57-8577-a72807b8fbff" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_87b04250-5bbf-4dae-9de1-75e337140b34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_e67ca6a2-04d8-40b7-8c4e-27c7bad26f76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_52b6c1ca-e965-4a57-8577-a72807b8fbff" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_e67ca6a2-04d8-40b7-8c4e-27c7bad26f76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_673f9942-191f-4921-93d3-91622ff797ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesAfterRollingYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_52b6c1ca-e965-4a57-8577-a72807b8fbff" xlink:to="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_673f9942-191f-4921-93d3-91622ff797ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_6dabffca-19f7-4bcb-bcee-0521738b7601" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_a3060a16-dd96-4e19-90e8-ce5cf763b368" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_6dabffca-19f7-4bcb-bcee-0521738b7601" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_a3060a16-dd96-4e19-90e8-ce5cf763b368" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_aefab59b-9f3d-428a-afb3-be14e52db570" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_6dabffca-19f7-4bcb-bcee-0521738b7601" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_aefab59b-9f3d-428a-afb3-be14e52db570" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_3c6c05ba-1ffa-4cfe-97b7-06b3d6252823" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_6dabffca-19f7-4bcb-bcee-0521738b7601" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_3c6c05ba-1ffa-4cfe-97b7-06b3d6252823" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_799f4996-0f94-43f5-8f07-6c4a8bc035f4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_6dabffca-19f7-4bcb-bcee-0521738b7601" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_799f4996-0f94-43f5-8f07-6c4a8bc035f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_ac5e5cb0-99fb-43a1-93e0-8164a6a5e6ed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_6dabffca-19f7-4bcb-bcee-0521738b7601" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_ac5e5cb0-99fb-43a1-93e0-8164a6a5e6ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_aa5a6518-fdfc-4570-9eb2-01d0167a0988" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_6dabffca-19f7-4bcb-bcee-0521738b7601" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_aa5a6518-fdfc-4570-9eb2-01d0167a0988" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_cad8c8ec-a78a-4e5f-9cea-7c4327bf481b" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_9c559e04-bdf8-4bf5-b2a9-3265c05037f4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_cad8c8ec-a78a-4e5f-9cea-7c4327bf481b" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_9c559e04-bdf8-4bf5-b2a9-3265c05037f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_e39fc622-96ca-415f-a158-8f4188fc8110" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_cad8c8ec-a78a-4e5f-9cea-7c4327bf481b" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_e39fc622-96ca-415f-a158-8f4188fc8110" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_161a8d37-9223-495c-a752-9fe96faff91c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_cad8c8ec-a78a-4e5f-9cea-7c4327bf481b" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_161a8d37-9223-495c-a752-9fe96faff91c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_f21bb9bd-0a9f-4bec-a9e3-027f5acdb6a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_cdcb7b32-9ac9-4041-988b-610287d642ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_f21bb9bd-0a9f-4bec-a9e3-027f5acdb6a2" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_cdcb7b32-9ac9-4041-988b-610287d642ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_dfb6e6f9-3d79-43e2-b9b1-e44357160ec0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_f21bb9bd-0a9f-4bec-a9e3-027f5acdb6a2" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_dfb6e6f9-3d79-43e2-b9b1-e44357160ec0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_92ad6bc0-aad5-40d6-a179-c5943b4ce3f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_f21bb9bd-0a9f-4bec-a9e3-027f5acdb6a2" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_92ad6bc0-aad5-40d6-a179-c5943b4ce3f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_9a241eed-e57f-4f0b-9338-6329679dc029" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_f21bb9bd-0a9f-4bec-a9e3-027f5acdb6a2" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_9a241eed-e57f-4f0b-9338-6329679dc029" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_02798157-17b3-4fbb-af5f-1637ceb94d58" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_f21bb9bd-0a9f-4bec-a9e3-027f5acdb6a2" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_02798157-17b3-4fbb-af5f-1637ceb94d58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_e8c4c964-f4d5-4ee8-a433-4f346da7f4e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_f21bb9bd-0a9f-4bec-a9e3-027f5acdb6a2" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_e8c4c964-f4d5-4ee8-a433-4f346da7f4e9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/TimeDepositsandBorrowingsDetails_1" xlink:type="simple" xlink:href="cfb-20200930.xsd#TimeDepositsandBorrowingsDetails_1"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/TimeDepositsandBorrowingsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowings_77f3c9c8-350e-4b02-a541-3737b97be064" xlink:href="cfb-20200930.xsd#cfb_TimeDepositMaturitiesAndBorrowings"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_415c0301-165e-40ba-944d-a260660ffac8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_77f3c9c8-350e-4b02-a541-3737b97be064" xlink:to="loc_us-gaap_TimeDeposits_415c0301-165e-40ba-944d-a260660ffac8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_dc88a4f7-d538-4a81-ad4b-832230de9bfa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_77f3c9c8-350e-4b02-a541-3737b97be064" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_dc88a4f7-d538-4a81-ad4b-832230de9bfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_9e5c920c-fcc1-4af6-a684-8160f2b6c87a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_77f3c9c8-350e-4b02-a541-3737b97be064" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_9e5c920c-fcc1-4af6-a684-8160f2b6c87a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_99a55ff1-c4e4-4525-a4d8-638abbe234c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_77f3c9c8-350e-4b02-a541-3737b97be064" xlink:to="loc_us-gaap_LongTermDebt_99a55ff1-c4e4-4525-a4d8-638abbe234c7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ChangeinAccumulatedOtherComprehensiveIncomeAOCI" xlink:type="simple" xlink:href="cfb-20200930.xsd#ChangeinAccumulatedOtherComprehensiveIncomeAOCI"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ChangeinAccumulatedOtherComprehensiveIncomeAOCI" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ChangeinAccumulatedOtherComprehensiveIncomeAOCITables" xlink:type="simple" xlink:href="cfb-20200930.xsd#ChangeinAccumulatedOtherComprehensiveIncomeAOCITables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ChangeinAccumulatedOtherComprehensiveIncomeAOCITables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ChangeinAccumulatedOtherComprehensiveIncomeAOCIDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#ChangeinAccumulatedOtherComprehensiveIncomeAOCIDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ChangeinAccumulatedOtherComprehensiveIncomeAOCIDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RegulatoryMatters" xlink:type="simple" xlink:href="cfb-20200930.xsd#RegulatoryMatters"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RegulatoryMatters" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RegulatoryMattersTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#RegulatoryMattersTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RegulatoryMattersTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RegulatoryMattersDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#RegulatoryMattersDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RegulatoryMattersDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="cfb-20200930.xsd#StockBasedCompensation"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensation" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#StockBasedCompensationTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationTotalStockBasedCompensationDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#StockBasedCompensationTotalStockBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationTotalStockBasedCompensationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationStatusandChangesinPerformanceBasedAwardsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#StockBasedCompensationStatusandChangesinPerformanceBasedAwardsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationStatusandChangesinPerformanceBasedAwardsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationStatusandChangesinRSUsandRSAsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#StockBasedCompensationStatusandChangesinRSUsandRSAsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationStatusandChangesinRSUsandRSAsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTax" xlink:type="simple" xlink:href="cfb-20200930.xsd#IncomeTax"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTax" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#IncomeTaxTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxEffectiveIncomeTaxReconciliationDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#IncomeTaxEffectiveIncomeTaxReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxEffectiveIncomeTaxReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_3224abd2-e86a-4ad1-bdf6-6c75172afaef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_3224abd2-e86a-4ad1-bdf6-6c75172afaef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses_c8cd2292-9ed3-4951-8646-b9005e49177b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses_c8cd2292-9ed3-4951-8646-b9005e49177b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_d61b59da-f203-4bf6-a613-72414a552716" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_d61b59da-f203-4bf6-a613-72414a552716" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxExemptIncome_22989278-dd6e-4285-92d7-2b67dedc6807" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxExemptIncome"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxExemptIncome_22989278-dd6e-4285-92d7-2b67dedc6807" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_c161876c-b4bd-4913-95fd-ff138f34cb50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_c161876c-b4bd-4913-95fd-ff138f34cb50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCredits_7eda4b72-7814-4c9d-a74e-06331a2b3599" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCredits"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCredits_7eda4b72-7814-4c9d-a74e-06331a2b3599" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_00c9eca9-cf00-4149-8091-e827fbf833c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_00c9eca9-cf00-4149-8091-e827fbf833c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_19df021b-c51c-4a43-b693-d01f86fd6a1e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_1b0768e6-5534-41e4-af1b-04db6e512ecc" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_19df021b-c51c-4a43-b693-d01f86fd6a1e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#IncomeTaxDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_a57fd29f-7f02-4701-a551-15ef428da1d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_a57fd29f-7f02-4701-a551-15ef428da1d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxAssetsLeaseIncentive_c487128c-fd55-46a7-a3df-a1ad0be6d065" xlink:href="cfb-20200930.xsd#cfb_DeferredTaxAssetsLeaseIncentive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_cfb_DeferredTaxAssetsLeaseIncentive_c487128c-fd55-46a7-a3df-a1ad0be6d065" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsImpairmentLosses_4c65fd35-00da-4fde-8978-a78d15b7d6ff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsImpairmentLosses"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsImpairmentLosses_4c65fd35-00da-4fde-8978-a78d15b7d6ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxAssetsLoanFees_cf6986e2-0e95-40bd-8f4b-80ae2d1c2bdd" xlink:href="cfb-20200930.xsd#cfb_DeferredTaxAssetsLoanFees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_cfb_DeferredTaxAssetsLoanFees_cf6986e2-0e95-40bd-8f4b-80ae2d1c2bdd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_d1d7b38d-09ec-48c0-b3a7-6b7dfda6bf53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_d1d7b38d-09ec-48c0-b3a7-6b7dfda6bf53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_521cdc23-ed06-497b-93b0-d7f0754f6e81" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_521cdc23-ed06-497b-93b0-d7f0754f6e81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_20b08ed2-4ad6-40fa-92c7-3f2da44bb0bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_20b08ed2-4ad6-40fa-92c7-3f2da44bb0bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsStateTaxes_7f8cea94-7499-4bfe-86a7-0cfab53d0642" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsStateTaxes"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_us-gaap_DeferredTaxAssetsStateTaxes_7f8cea94-7499-4bfe-86a7-0cfab53d0642" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_cfad91f2-def3-4ac0-aa9b-ebebf2a6708a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_cfad91f2-def3-4ac0-aa9b-ebebf2a6708a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxAssetsValuationAllowanceOnRealEstate_e50a770e-1109-4eb3-904d-d45fe66eaca3" xlink:href="cfb-20200930.xsd#cfb_DeferredTaxAssetsValuationAllowanceOnRealEstate"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_3c0e1db7-4353-420f-b5ba-1991103cc41b" xlink:to="loc_cfb_DeferredTaxAssetsValuationAllowanceOnRealEstate_e50a770e-1109-4eb3-904d-d45fe66eaca3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_db2efe08-49c0-46f8-862b-9e7384842a25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_8c8ee9ff-f7e9-472a-be64-9be37d2a1d2b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_db2efe08-49c0-46f8-862b-9e7384842a25" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_8c8ee9ff-f7e9-472a-be64-9be37d2a1d2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_58d5eb51-fb80-4368-a90f-bcf3c2cdd85c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_db2efe08-49c0-46f8-862b-9e7384842a25" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_58d5eb51-fb80-4368-a90f-bcf3c2cdd85c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_98d2a241-5e57-4677-93b8-e068a2bc7705" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxLiabilitiesFairMarketValueAdjustmentsOnSecurities_460f5b2d-0a40-4e0e-a99e-87febdda8663" xlink:href="cfb-20200930.xsd#cfb_DeferredTaxLiabilitiesFairMarketValueAdjustmentsOnSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_98d2a241-5e57-4677-93b8-e068a2bc7705" xlink:to="loc_cfb_DeferredTaxLiabilitiesFairMarketValueAdjustmentsOnSecurities_460f5b2d-0a40-4e0e-a99e-87febdda8663" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxLiabilitiesUnrealizedGainsOnAvailableForSaleSecurities_1d7b8bb8-24df-4f89-bfe4-eade6e7fb839" xlink:href="cfb-20200930.xsd#cfb_DeferredTaxLiabilitiesUnrealizedGainsOnAvailableForSaleSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_98d2a241-5e57-4677-93b8-e068a2bc7705" xlink:to="loc_cfb_DeferredTaxLiabilitiesUnrealizedGainsOnAvailableForSaleSecurities_1d7b8bb8-24df-4f89-bfe4-eade6e7fb839" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxLiabilitiesFederalHomeLoanBankBasis_1e03f4a0-0b20-4955-a5d7-9e0f0f2b9907" xlink:href="cfb-20200930.xsd#cfb_DeferredTaxLiabilitiesFederalHomeLoanBankBasis"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_98d2a241-5e57-4677-93b8-e068a2bc7705" xlink:to="loc_cfb_DeferredTaxLiabilitiesFederalHomeLoanBankBasis_1e03f4a0-0b20-4955-a5d7-9e0f0f2b9907" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_efcdbda5-72e0-4763-a641-c8f4a3160c55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_98d2a241-5e57-4677-93b8-e068a2bc7705" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_efcdbda5-72e0-4763-a641-c8f4a3160c55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_4e14acca-855c-4e64-bdaa-a9c5e5023593" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_98d2a241-5e57-4677-93b8-e068a2bc7705" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_4e14acca-855c-4e64-bdaa-a9c5e5023593" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstruments" xlink:type="simple" xlink:href="cfb-20200930.xsd#DisclosuresaboutFairValueofFinancialInstruments"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstruments" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#DisclosuresaboutFairValueofFinancialInstrumentsTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsNonrecurringMeasurementsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#DisclosuresaboutFairValueofFinancialInstrumentsNonrecurringMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsNonrecurringMeasurementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsUnobservableInputsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#DisclosuresaboutFairValueofFinancialInstrumentsUnobservableInputsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsUnobservableInputsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#DisclosuresaboutFairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_3f03ae7d-b134-43a6-9dee-b9bacbea71cc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsFairValueDisclosure_c6fde75f-1742-47d5-9d16-1a04df010ee0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepositsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_3f03ae7d-b134-43a6-9dee-b9bacbea71cc" xlink:to="loc_us-gaap_DepositsFairValueDisclosure_c6fde75f-1742-47d5-9d16-1a04df010ee0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_659839ed-edaf-40ae-a0d4-21d17db09802" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_3f03ae7d-b134-43a6-9dee-b9bacbea71cc" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_659839ed-edaf-40ae-a0d4-21d17db09802" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure_9075bda3-ffcb-4305-8211-635df665be15" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_3f03ae7d-b134-43a6-9dee-b9bacbea71cc" xlink:to="loc_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure_9075bda3-ffcb-4305-8211-635df665be15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_OtherBorrowingsFairValueDisclosure_c09cf515-f805-4d9f-bfd5-9e937880024b" xlink:href="cfb-20200930.xsd#cfb_OtherBorrowingsFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_3f03ae7d-b134-43a6-9dee-b9bacbea71cc" xlink:to="loc_cfb_OtherBorrowingsFairValueDisclosure_c09cf515-f805-4d9f-bfd5-9e937880024b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_InterestPayableFairValueDisclosure_d72b4b94-e507-4d18-9ff6-6e052ed97c4e" xlink:href="cfb-20200930.xsd#cfb_InterestPayableFairValueDisclosure"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_3f03ae7d-b134-43a6-9dee-b9bacbea71cc" xlink:to="loc_cfb_InterestPayableFairValueDisclosure_d72b4b94-e507-4d18-9ff6-6e052ed97c4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_85ded71f-b318-4128-a220-17bae5e41838" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_3f03ae7d-b134-43a6-9dee-b9bacbea71cc" xlink:to="loc_us-gaap_DerivativeLiabilities_85ded71f-b318-4128-a220-17bae5e41838" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_eed67bc5-7b0a-40b0-a07f-ea12c67ae901" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_ef092ad0-e153-4e2f-95f9-91eadf2817ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_eed67bc5-7b0a-40b0-a07f-ea12c67ae901" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_ef092ad0-e153-4e2f-95f9-91eadf2817ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5eeea32a-2a8f-4011-b430-ec6abe91b0e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_eed67bc5-7b0a-40b0-a07f-ea12c67ae901" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5eeea32a-2a8f-4011-b430-ec6abe91b0e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_72921e13-7e82-4364-8e21-7e2442628eaa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_eed67bc5-7b0a-40b0-a07f-ea12c67ae901" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_72921e13-7e82-4364-8e21-7e2442628eaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRestricted_9c686f1d-1536-466c-9fe2-fa7b8b508319" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiRestricted"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_eed67bc5-7b0a-40b0-a07f-ea12c67ae901" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRestricted_9c686f1d-1536-466c-9fe2-fa7b8b508319" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_InterestReceivableFairValueDisclosure_8bd1240f-79d6-478b-b891-29c654a99c62" xlink:href="cfb-20200930.xsd#cfb_InterestReceivableFairValueDisclosure"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_eed67bc5-7b0a-40b0-a07f-ea12c67ae901" xlink:to="loc_cfb_InterestReceivableFairValueDisclosure_8bd1240f-79d6-478b-b891-29c654a99c62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_909075af-f052-4822-b309-42dcb9c62008" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_eed67bc5-7b0a-40b0-a07f-ea12c67ae901" xlink:to="loc_us-gaap_DerivativeAssets_909075af-f052-4822-b309-42dcb9c62008" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CommitmentsandCreditRisk" xlink:type="simple" xlink:href="cfb-20200930.xsd#CommitmentsandCreditRisk"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CommitmentsandCreditRisk" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskTables" xlink:type="simple" xlink:href="cfb-20200930.xsd#CommitmentsandCreditRiskTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#CommitmentsandCreditRiskDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LegalandRegulatoryProceedings" xlink:type="simple" xlink:href="cfb-20200930.xsd#LegalandRegulatoryProceedings"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LegalandRegulatoryProceedings" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SubsequentEvents" xlink:type="simple" xlink:href="cfb-20200930.xsd#SubsequentEvents"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SubsequentEvents" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="cfb-20200930.xsd#SubsequentEventsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SubsequentEventsDetails" xlink:type="extended"/>
</link:linkbase>
