<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:9f24aa56-ab87-4750-a8b2-00ff3d1b816b,g:995f2791-478f-4e97-a6db-da548147db3d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CoverPage" xlink:type="simple" xlink:href="cfb-20201231.xsd#CoverPage"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CoverPage" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="cfb-20201231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_54a85c3a-caea-47d8-bb13-8c9a392922a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_d31d9bc2-e8be-4ec7-bc3e-24e8e418bdf8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_54a85c3a-caea-47d8-bb13-8c9a392922a5" xlink:to="loc_us-gaap_CommonStockValue_d31d9bc2-e8be-4ec7-bc3e-24e8e418bdf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_8dfb985e-858d-4d5b-85aa-2ce4710eaf80" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_54a85c3a-caea-47d8-bb13-8c9a392922a5" xlink:to="loc_us-gaap_AdditionalPaidInCapital_8dfb985e-858d-4d5b-85aa-2ce4710eaf80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_da9c2de9-6515-46ed-a028-ba1c53aef4c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_54a85c3a-caea-47d8-bb13-8c9a392922a5" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_da9c2de9-6515-46ed-a028-ba1c53aef4c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_66625d1a-7c1c-49ec-9161-69dd97def0f8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_54a85c3a-caea-47d8-bb13-8c9a392922a5" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_66625d1a-7c1c-49ec-9161-69dd97def0f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_152783ec-681f-4cc7-8744-d8154f1019f0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_54a85c3a-caea-47d8-bb13-8c9a392922a5" xlink:to="loc_us-gaap_TreasuryStockValue_152783ec-681f-4cc7-8744-d8154f1019f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_3044c5fa-a7f9-436a-ab09-491a955b6f2f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_143ee2ca-f03f-432f-aef2-332d175461fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3044c5fa-a7f9-436a-ab09-491a955b6f2f" xlink:to="loc_us-gaap_Deposits_143ee2ca-f03f-432f-aef2-332d175461fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_7424525d-8436-4bdd-b89a-3c1eb69499f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3044c5fa-a7f9-436a-ab09-491a955b6f2f" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_7424525d-8436-4bdd-b89a-3c1eb69499f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_17139b0c-eb7b-42bd-8e07-a92845f2c94d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3044c5fa-a7f9-436a-ab09-491a955b6f2f" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_17139b0c-eb7b-42bd-8e07-a92845f2c94d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherBorrowings_684d3309-63fb-4fde-bf9b-9265c4fc780b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherBorrowings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3044c5fa-a7f9-436a-ab09-491a955b6f2f" xlink:to="loc_us-gaap_OtherBorrowings_684d3309-63fb-4fde-bf9b-9265c4fc780b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_InterestPayableAndOtherLiabilities_71b1de94-cf37-47b4-8fbc-58cc41b2d6c0" xlink:href="cfb-20201231.xsd#cfb_InterestPayableAndOtherLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3044c5fa-a7f9-436a-ab09-491a955b6f2f" xlink:to="loc_cfb_InterestPayableAndOtherLiabilities_71b1de94-cf37-47b4-8fbc-58cc41b2d6c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_c077897e-0855-4acc-8e81-ac5e9674fe58" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3044c5fa-a7f9-436a-ab09-491a955b6f2f" xlink:to="loc_us-gaap_OtherLiabilities_c077897e-0855-4acc-8e81-ac5e9674fe58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_ed7d916c-5eed-4f65-b142-e599021dbff5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_c611202a-cd2f-4685-b00d-26c2c621a00f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_ed7d916c-5eed-4f65-b142-e599021dbff5" xlink:to="loc_us-gaap_Liabilities_c611202a-cd2f-4685-b00d-26c2c621a00f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_eb3023de-b2d5-492e-9e63-9677597cbcd2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_ed7d916c-5eed-4f65-b142-e599021dbff5" xlink:to="loc_us-gaap_StockholdersEquity_eb3023de-b2d5-492e-9e63-9677597cbcd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_103ca976-2aaf-4d39-bd0e-e7dd96ae7d5d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_d1a200f6-91c3-48e0-8e4a-7744fddb43e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_103ca976-2aaf-4d39-bd0e-e7dd96ae7d5d" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_d1a200f6-91c3-48e0-8e4a-7744fddb43e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW_129e120b-3411-46d1-bd1a-8a4846dfe4b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_103ca976-2aaf-4d39-bd0e-e7dd96ae7d5d" xlink:to="loc_us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW_129e120b-3411-46d1-bd1a-8a4846dfe4b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_e9956283-6467-47bc-8db6-7dd20ace34d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_103ca976-2aaf-4d39-bd0e-e7dd96ae7d5d" xlink:to="loc_us-gaap_TimeDeposits_e9956283-6467-47bc-8db6-7dd20ace34d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6caef7a9-d7f2-4a73-ab56-32c119e34473" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6caef7a9-d7f2-4a73-ab56-32c119e34473" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_ShortTermInvestmentsTaxExempt_d25bd1a3-ef39-45e1-9d71-f2821abe00f6" xlink:href="cfb-20201231.xsd#cfb_ShortTermInvestmentsTaxExempt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_cfb_ShortTermInvestmentsTaxExempt_d25bd1a3-ef39-45e1-9d71-f2821abe00f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_ShortTermInvestmentsTaxable_89513173-7c80-4775-8bda-e0868c802f4b" xlink:href="cfb-20201231.xsd#cfb_ShortTermInvestmentsTaxable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_cfb_ShortTermInvestmentsTaxable_89513173-7c80-4775-8bda-e0868c802f4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_080f9c25-e512-4651-8779-3e5d5e05f09e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_NotesReceivableNet_080f9c25-e512-4651-8779-3e5d5e05f09e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_52480965-2e1c-4e4a-89d2-2cd9d37552df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_52480965-2e1c-4e4a-89d2-2cd9d37552df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRestricted_fdc9b8e7-8852-4495-b333-e747c2a8dcb7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiRestricted"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRestricted_fdc9b8e7-8852-4495-b333-e747c2a8dcb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivable_528a49a0-271b-4549-b668-256ecd00080a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestReceivable"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_InterestReceivable_528a49a0-271b-4549-b668-256ecd00080a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_RepossessedAssetsHeldForSale_878ea8dc-1e55-4659-815c-15c2cc9fdbfa" xlink:href="cfb-20201231.xsd#cfb_RepossessedAssetsHeldForSale"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_cfb_RepossessedAssetsHeldForSale_878ea8dc-1e55-4659-815c-15c2cc9fdbfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ab5f3f83-2e9f-45b9-99bf-89e2755576f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ab5f3f83-2e9f-45b9-99bf-89e2755576f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsurance_dff222a4-bbc0-4faa-bbbb-d3d26aee2292" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BankOwnedLifeInsurance"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_BankOwnedLifeInsurance_dff222a4-bbc0-4faa-bbbb-d3d26aee2292" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_74ec83a8-bb97-47fa-b9de-0716504cc97a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_OtherAssets_74ec83a8-bb97-47fa-b9de-0716504cc97a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_243e7bf6-5e60-491b-902e-86ae998b320f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_4f2346b7-1d02-4ce1-bf62-65e7b4da1f97" xlink:to="loc_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_243e7bf6-5e60-491b-902e-86ae998b320f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="cfb-20201231.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofIncome" xlink:type="simple" xlink:href="cfb-20201231.xsd#ConsolidatedStatementsofIncome"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b72a4e73-e971-40dc-b9dd-53d50a334861" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b72a4e73-e971-40dc-b9dd-53d50a334861" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnInvestments_c8bba396-6712-4489-b98a-4dad6920f7d0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:to="loc_us-gaap_GainLossOnInvestments_c8bba396-6712-4489-b98a-4dad6920f7d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_0087b05e-be09-4131-bac1-5cab5bb9aab1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_0087b05e-be09-4131-bac1-5cab5bb9aab1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfLoansNet_a519cbda-2be6-4c26-82e9-a76c23c9c428" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSalesOfLoansNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:to="loc_us-gaap_GainLossOnSalesOfLoansNet_a519cbda-2be6-4c26-82e9-a76c23c9c428" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_3e082d13-0f66-456d-bd1e-88448dbaed86" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_3e082d13-0f66-456d-bd1e-88448dbaed86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_c2358a3a-7989-425c-8c5d-e08e02be65ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:to="loc_us-gaap_GainLossOnDerivativeInstrumentsNetPretax_c2358a3a-7989-425c-8c5d-e08e02be65ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_247eaca0-9dd5-4351-9a71-96e6d35a4535" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_839854f6-0c4f-4485-bd00-4cc8fd05095d" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_247eaca0-9dd5-4351-9a71-96e6d35a4535" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3edddf82-e5dc-4e38-9c5f-5cf106ffea73" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_17328092-37c8-47af-851e-3a1e8e119641" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_3edddf82-e5dc-4e38-9c5f-5cf106ffea73" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_17328092-37c8-47af-851e-3a1e8e119641" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_3f244942-e337-4657-9d29-a45b0593fc77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_3edddf82-e5dc-4e38-9c5f-5cf106ffea73" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_3f244942-e337-4657-9d29-a45b0593fc77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_a28d6484-b4f6-4808-9d24-288b2dd64ec9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_10738e8b-dd36-4735-b9d2-781619f102d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_a28d6484-b4f6-4808-9d24-288b2dd64ec9" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_10738e8b-dd36-4735-b9d2-781619f102d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_b324f03e-3e8e-47da-b005-8479d64f3306" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_a28d6484-b4f6-4808-9d24-288b2dd64ec9" xlink:to="loc_us-gaap_InterestExpense_b324f03e-3e8e-47da-b005-8479d64f3306" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_cb171456-4a9a-4997-a44a-0409826193ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_09a86d55-568b-49cc-ba50-6cdb6da3872e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_cb171456-4a9a-4997-a44a-0409826193ef" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_09a86d55-568b-49cc-ba50-6cdb6da3872e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_dd9a4644-01a8-416f-b54a-0a0fb607d628" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_cb171456-4a9a-4997-a44a-0409826193ef" xlink:to="loc_us-gaap_NoninterestIncome_dd9a4644-01a8-416f-b54a-0a0fb607d628" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_22d32b12-5307-4f38-8c1b-28028f643808" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_cb171456-4a9a-4997-a44a-0409826193ef" xlink:to="loc_us-gaap_NoninterestExpense_22d32b12-5307-4f38-8c1b-28028f643808" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_170cbd6b-3ae2-4845-af33-240e8cca59aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_5737b953-a4e4-46cc-8e16-080eb921ecc2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_170cbd6b-3ae2-4845-af33-240e8cca59aa" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_5737b953-a4e4-46cc-8e16-080eb921ecc2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_49bd02b9-bc3a-45bf-a658-0a87967cf2ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_170cbd6b-3ae2-4845-af33-240e8cca59aa" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_49bd02b9-bc3a-45bf-a658-0a87967cf2ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_158f99a9-35a0-40dd-a7fd-9d33e08db6f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_b74da926-d856-4219-be09-09a23f1c4b05" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_158f99a9-35a0-40dd-a7fd-9d33e08db6f6" xlink:to="loc_us-gaap_InterestExpenseDeposits_b74da926-d856-4219-be09-09a23f1c4b05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_9c41586c-6751-4b74-a389-bec6a65d5326" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_158f99a9-35a0-40dd-a7fd-9d33e08db6f6" xlink:to="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_9c41586c-6751-4b74-a389-bec6a65d5326" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesShortTerm_6b0f0d2b-52e6-494f-99fc-cb1c78fc7e71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesShortTerm"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_158f99a9-35a0-40dd-a7fd-9d33e08db6f6" xlink:to="loc_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesShortTerm_6b0f0d2b-52e6-494f-99fc-cb1c78fc7e71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOtherShortTermBorrowings_f4ddb5c8-0a77-45a3-9912-d89a963a729a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseOtherShortTermBorrowings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_158f99a9-35a0-40dd-a7fd-9d33e08db6f6" xlink:to="loc_us-gaap_InterestExpenseOtherShortTermBorrowings_f4ddb5c8-0a77-45a3-9912-d89a963a729a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_13247478-5f97-4957-b7e1-bdff05a306c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_OccupancyNet_13247478-5f97-4957-b7e1-bdff05a306c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_eb31665a-2d01-4848-917e-cd811adc0450" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_eb31665a-2d01-4848-917e-cd811adc0450" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_babef07c-d58e-41db-a5c6-9bfe7f6c8468" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_OtherNoninterestExpense_babef07c-d58e-41db-a5c6-9bfe7f6c8468" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_e0002e6b-fbfb-4cc8-9d05-dd5b03ddf2ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProfessionalFees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_ProfessionalFees_e0002e6b-fbfb-4cc8-9d05-dd5b03ddf2ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvertisingExpense_862d2c8e-751d-4b5f-b38d-26b0081ae219" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvertisingExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_AdvertisingExpense_862d2c8e-751d-4b5f-b38d-26b0081ae219" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeclosedRealEstateExpense_ffe4912c-2bee-418c-b917-8f5eea9de9aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeclosedRealEstateExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_ForeclosedRealEstateExpense_ffe4912c-2bee-418c-b917-8f5eea9de9aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_61fc5f82-c5c5-4622-9a46-5325cab8301a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalDepositInsuranceCorporationPremiumExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_61fc5f82-c5c5-4622-9a46-5325cab8301a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Communication_70656a28-4d5f-410a-b25b-0106e007e211" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Communication"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_Communication_70656a28-4d5f-410a-b25b-0106e007e211" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_0b203bde-c3e8-437b-81e3-c31a779e0fbb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_0b203bde-c3e8-437b-81e3-c31a779e0fbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_e88cbb7a-826f-4bec-a4c6-2a2819aa8e6f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_bc2e74d6-dba3-46bc-92ec-361c0a772f3f" xlink:to="loc_us-gaap_LaborAndRelatedExpense_e88cbb7a-826f-4bec-a4c6-2a2819aa8e6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_a2fe67a3-d1f0-4930-9aaf-62080f85093c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_8cca208f-f460-44e3-882e-cb4f2cfe4a2e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_a2fe67a3-d1f0-4930-9aaf-62080f85093c" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_8cca208f-f460-44e3-882e-cb4f2cfe4a2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_929ae54a-a2d1-4745-8e64-96c837020ca3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_a2fe67a3-d1f0-4930-9aaf-62080f85093c" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_929ae54a-a2d1-4745-8e64-96c837020ca3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_5e50131e-7a2a-4fb7-815f-2c6c9a293ace" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_a2fe67a3-d1f0-4930-9aaf-62080f85093c" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_5e50131e-7a2a-4fb7-815f-2c6c9a293ace" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_6bccdd9b-d40d-4756-898e-3526a84b229b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeDepositsWithFinancialInstitutions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_a2fe67a3-d1f0-4930-9aaf-62080f85093c" xlink:to="loc_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_6bccdd9b-d40d-4756-898e-3526a84b229b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendIncomeOperating_97f40d7c-d3e0-4e7e-a531-670e0316b4ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DividendIncomeOperating"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_a2fe67a3-d1f0-4930-9aaf-62080f85093c" xlink:to="loc_us-gaap_DividendIncomeOperating_97f40d7c-d3e0-4e7e-a531-670e0316b4ee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="cfb-20201231.xsd#ConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_46fcb6e5-f0a6-432c-99f1-0ed0f3c1f0d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_f72719da-f70c-401f-a16b-b0cb870f8c79" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_46fcb6e5-f0a6-432c-99f1-0ed0f3c1f0d5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_f72719da-f70c-401f-a16b-b0cb870f8c79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_b320dd2e-8218-4831-9fe1-afdad1f177ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_46fcb6e5-f0a6-432c-99f1-0ed0f3c1f0d5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_b320dd2e-8218-4831-9fe1-afdad1f177ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_832141a8-924a-49bc-ad89-29303384bfa0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_56301997-cfb1-4e68-b614-80c8952c4600" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_832141a8-924a-49bc-ad89-29303384bfa0" xlink:to="loc_us-gaap_NetIncomeLoss_56301997-cfb1-4e68-b614-80c8952c4600" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_62dc3a60-b75d-493f-b5d5-fd4b17261471" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_832141a8-924a-49bc-ad89-29303384bfa0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_62dc3a60-b75d-493f-b5d5-fd4b17261471" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_a6e56b18-bdd3-4a3d-ab0c-9c4b067f2c66" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_139ff742-fa0c-4e3d-b6f1-9ca25d467830" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_a6e56b18-bdd3-4a3d-ab0c-9c4b067f2c66" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_139ff742-fa0c-4e3d-b6f1-9ca25d467830" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_1c73a73a-e664-4e5e-80e8-e023b39f7eab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_a6e56b18-bdd3-4a3d-ab0c-9c4b067f2c66" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_1c73a73a-e664-4e5e-80e8-e023b39f7eab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_170da2d1-468f-45b1-92dd-3bb189e387f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_fea556d9-55ea-4e67-b92d-32bd27b44185" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_170da2d1-468f-45b1-92dd-3bb189e387f7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_fea556d9-55ea-4e67-b92d-32bd27b44185" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_118f0fe4-a009-45e7-a9f7-9045080df28b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_170da2d1-468f-45b1-92dd-3bb189e387f7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_118f0fe4-a009-45e7-a9f7-9045080df28b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="cfb-20201231.xsd#ConsolidatedStatementsofStockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofStockholdersEquityParenthetical" xlink:type="simple" xlink:href="cfb-20201231.xsd#ConsolidatedStatementsofStockholdersEquityParenthetical"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofStockholdersEquityParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="cfb-20201231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromLoansReceivable_a90931f2-216b-4d5d-aee5-8b7c93c819c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForProceedsFromLoansReceivable"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_PaymentsForProceedsFromLoansReceivable_a90931f2-216b-4d5d-aee5-8b7c93c819c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_3039f82a-9179-4a14-918c-f8300e446bd1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_3039f82a-9179-4a14-918c-f8300e446bd1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_0768dde2-7b3e-4726-9e58-7f12592fb919" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_0768dde2-7b3e-4726-9e58-7f12592fb919" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_9ede2e9a-b13a-4895-8bd7-ffcd34128280" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_9ede2e9a-b13a-4895-8bd7-ffcd34128280" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfForeclosedAssets_3ad2ca25-606d-46ca-ba9b-704fbefcff8b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfForeclosedAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_ProceedsFromSaleOfForeclosedAssets_3ad2ca25-606d-46ca-ba9b-704fbefcff8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_cacd3294-51e1-4db9-b918-f6fa8d90464c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_cacd3294-51e1-4db9-b918-f6fa8d90464c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireRestrictedInvestments_aa9b69fc-6acd-4f66-bffd-b9d271f0074c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireRestrictedInvestments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_PaymentsToAcquireRestrictedInvestments_aa9b69fc-6acd-4f66-bffd-b9d271f0074c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_f01710b9-737b-4a6c-8497-7a97c4d6aeaa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_f01710b9-737b-4a6c-8497-7a97c4d6aeaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfRestrictedInvestments_48bd067f-4b7b-4431-b0a0-71439ba4c5ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfRestrictedInvestments"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_ProceedsFromSaleOfRestrictedInvestments_48bd067f-4b7b-4431-b0a0-71439ba4c5ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInterestInSubsidiariesAndAffiliates_30701694-1231-4d3b-862f-8a555ac37a4e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireInterestInSubsidiariesAndAffiliates"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94e72a0c-c61a-46b0-9e27-7fc14294f0a7" xlink:to="loc_us-gaap_PaymentsToAcquireInterestInSubsidiariesAndAffiliates_30701694-1231-4d3b-862f-8a555ac37a4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_IncreaseDecreaseInDemandDepositsSavingsNOWandMoneyMarketAccounts_1b6243df-34f8-4942-b929-4c74ef8b5476" xlink:href="cfb-20201231.xsd#cfb_IncreaseDecreaseInDemandDepositsSavingsNOWandMoneyMarketAccounts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_cfb_IncreaseDecreaseInDemandDepositsSavingsNOWandMoneyMarketAccounts_1b6243df-34f8-4942-b929-4c74ef8b5476" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTimeDeposits_47512a8a-d135-4054-b376-3cc0beb02635" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInTimeDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_IncreaseDecreaseInTimeDeposits_47512a8a-d135-4054-b376-3cc0beb02635" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_c7e0e89e-d6f4-4ac4-ac0a-59218924e57a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_IncreaseDecreaseInFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchaseNet_c7e0e89e-d6f4-4ac4-ac0a-59218924e57a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromFederalHomeLoanBankBorrowings_47fa1078-995d-4553-9a7b-7ba359e9ae5e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromFederalHomeLoanBankBorrowings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_ProceedsFromFederalHomeLoanBankBorrowings_47fa1078-995d-4553-9a7b-7ba359e9ae5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_b4cba56e-7bb4-48a0-a6c4-3652251d38d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_RepaymentsOfFederalHomeLoanBankBorrowings_b4cba56e-7bb4-48a0-a6c4-3652251d38d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_ProceedsFromRepaymentsOfFHLBankBorrowings_d7077c67-8419-46a5-9c5c-b08390f9a31f" xlink:href="cfb-20201231.xsd#cfb_ProceedsFromRepaymentsOfFHLBankBorrowings"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_cfb_ProceedsFromRepaymentsOfFHLBankBorrowings_d7077c67-8419-46a5-9c5c-b08390f9a31f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_9f1cf325-2d31-4eff-a664-f08a1920b4b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_9f1cf325-2d31-4eff-a664-f08a1920b4b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_73988fb1-4196-4442-97db-809a2d1e742d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_73988fb1-4196-4442-97db-809a2d1e742d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_79a6d6c0-25e4-4aa4-be38-b9798beda2f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_ProceedsFromStockPlans_79a6d6c0-25e4-4aa4-be38-b9798beda2f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_2ae07f86-1c4a-4ff5-b8a2-a342ead78e3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_2ae07f86-1c4a-4ff5-b8a2-a342ead78e3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4f272652-ed9a-4026-9678-b2bca29fb0eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4f272652-ed9a-4026-9678-b2bca29fb0eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_IncreaseDecreaseInEmployeeReceivables_13be321e-d706-424a-935c-a77e8cfc4929" xlink:href="cfb-20201231.xsd#cfb_IncreaseDecreaseInEmployeeReceivables"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_cfb_IncreaseDecreaseInEmployeeReceivables_13be321e-d706-424a-935c-a77e8cfc4929" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_a9b0d9d7-da24-49f4-b145-5b9ae08262c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_a9b0d9d7-da24-49f4-b145-5b9ae08262c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsShareBasedLiabilitiesPaid_ae547c29-fca5-4318-99e3-7a7676d9e39c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsShareBasedLiabilitiesPaid"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f4d2bcb6-3e4c-4853-ae6a-04e9a2cde78f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsShareBasedLiabilitiesPaid_ae547c29-fca5-4318-99e3-7a7676d9e39c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_4a23aa97-3ac9-4f53-b43f-67812aff4b78" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0c884fd-f7b6-4a2d-9259-afd92c7446b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_4a23aa97-3ac9-4f53-b43f-67812aff4b78" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0c884fd-f7b6-4a2d-9259-afd92c7446b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_66a17202-9b90-42f4-8947-6deb9e0c6bb7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_4a23aa97-3ac9-4f53-b43f-67812aff4b78" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_66a17202-9b90-42f4-8947-6deb9e0c6bb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_691c83e8-308c-4b59-be80-78ea7f6fa24a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_4a23aa97-3ac9-4f53-b43f-67812aff4b78" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_691c83e8-308c-4b59-be80-78ea7f6fa24a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_40153ea5-a4fd-4964-855a-2f815ec1d612" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_NetIncomeLoss_40153ea5-a4fd-4964-855a-2f815ec1d612" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_a5bc2b95-c67f-4b72-8c80-bc7817657157" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_a5bc2b95-c67f-4b72-8c80-bc7817657157" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_f133b854-3bd4-4e3c-bfdd-f45c514c6acc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_f133b854-3bd4-4e3c-bfdd-f45c514c6acc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_58508bab-1618-4dfc-b353-9f4515bf16c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_58508bab-1618-4dfc-b353-9f4515bf16c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_9de0bf24-f61e-4576-ac8f-5685e9b0fe4c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_ShareBasedCompensation_9de0bf24-f61e-4576-ac8f-5685e9b0fe4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets_3a63240d-975d-4cbc-b098-09744e2cc297" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets_3a63240d-975d-4cbc-b098-09744e2cc297" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfLoansNet_cb836380-ee56-4d21-93e6-25ae7065389a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSalesOfLoansNet"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_GainLossOnSalesOfLoansNet_cb836380-ee56-4d21-93e6-25ae7065389a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_ec1e1e92-11d9-4405-8c11-e49f44c1e023" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_ec1e1e92-11d9-4405-8c11-e49f44c1e023" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_74265d10-1584-436b-872c-6856317d0f5f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_74265d10-1584-436b-872c-6856317d0f5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesRealizedGainLoss_ff2d22a1-fbc0-4343-b450-54f67259aac2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtAndEquitySecuritiesRealizedGainLoss"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesRealizedGainLoss_ff2d22a1-fbc0-4343-b450-54f67259aac2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_744db483-2b86-469f-91c8-e9d19f62ebb1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_744db483-2b86-469f-91c8-e9d19f62ebb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DividendsOnFederalHomeLoanBankStock_8b10b109-57a3-4566-acc4-3ed792369291" xlink:href="cfb-20201231.xsd#cfb_DividendsOnFederalHomeLoanBankStock"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_cfb_DividendsOnFederalHomeLoanBankStock_8b10b109-57a3-4566-acc4-3ed792369291" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_3a62bd87-73c1-49a6-8318-a64e65af2cd4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_3a62bd87-73c1-49a6-8318-a64e65af2cd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_0ef8701e-fa0b-4df8-9d25-6fbd464a463f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_0ef8701e-fa0b-4df8-9d25-6fbd464a463f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_2d8fe7b5-1a57-4c20-81fd-6b09c77be4ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_2d8fe7b5-1a57-4c20-81fd-6b09c77be4ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromSubsidiariesBeforeTax_7f64b395-8d2a-4ae8-bf79-5214ad5221ff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromSubsidiariesBeforeTax"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_IncomeLossFromSubsidiariesBeforeTax_7f64b395-8d2a-4ae8-bf79-5214ad5221ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_dfe33be7-f0ec-4776-86f9-489e033cabb6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_dfe33be7-f0ec-4776-86f9-489e033cabb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnSalesOfOtherRealEstate_caa4a361-04c4-4237-b260-2822d81821ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnSalesOfOtherRealEstate"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_GainsLossesOnSalesOfOtherRealEstate_caa4a361-04c4-4237-b260-2822d81821ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_0e9960e6-3f8e-4f38-83c5-fd747433ba10" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c71e2eed-9777-4824-a1a9-4da347607228" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_0e9960e6-3f8e-4f38-83c5-fd747433ba10" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="cfb-20201231.xsd#NatureofOperationsandSummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="cfb-20201231.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesPropertyPlantEquipmentUsefulLivesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#NatureofOperationsandSummaryofSignificantAccountingPoliciesPropertyPlantEquipmentUsefulLivesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/NatureofOperationsandSummaryofSignificantAccountingPoliciesPropertyPlantEquipmentUsefulLivesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EarningsPerShare" xlink:type="simple" xlink:href="cfb-20201231.xsd#EarningsPerShare"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EarningsPerShare" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EarningsPerShareTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#EarningsPerShareTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EarningsPerShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_05ef704a-6327-453c-9d87-3da155aa574d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_042e94fd-b66c-4519-be31-d580a513dad4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_05ef704a-6327-453c-9d87-3da155aa574d" xlink:to="loc_us-gaap_NetIncomeLoss_042e94fd-b66c-4519-be31-d580a513dad4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsAndOtherAdjustments_b94d7a5e-cd0f-4d7d-b593-65e2eb2ade16" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockDividendsAndOtherAdjustments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_05ef704a-6327-453c-9d87-3da155aa574d" xlink:to="loc_us-gaap_PreferredStockDividendsAndOtherAdjustments_b94d7a5e-cd0f-4d7d-b593-65e2eb2ade16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_51d2aeff-3eba-40e6-bc4e-4b005519a3d2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_63e98d0e-a6c2-4ff5-a946-f1aefb7ea39f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_51d2aeff-3eba-40e6-bc4e-4b005519a3d2" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_63e98d0e-a6c2-4ff5-a946-f1aefb7ea39f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_840a63f5-cea4-46ef-b1f9-a980b90a1655" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_51d2aeff-3eba-40e6-bc4e-4b005519a3d2" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_840a63f5-cea4-46ef-b1f9-a980b90a1655" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/Securities" xlink:type="simple" xlink:href="cfb-20201231.xsd#Securities"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/Securities" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValueofSecuritiesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesAmortizedCostandFairValueofSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostandFairValueofSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_30ed204d-fea3-4702-97b4-2cccfaa85cb8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_9984606e-e73b-4d64-b191-51ee6c0436dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_30ed204d-fea3-4702-97b4-2cccfaa85cb8" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_9984606e-e73b-4d64-b191-51ee6c0436dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_afe5a5e5-9276-4357-95bd-5a969297c5fa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_30ed204d-fea3-4702-97b4-2cccfaa85cb8" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_afe5a5e5-9276-4357-95bd-5a969297c5fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_99bac6cf-1092-46c9-8d49-27765967a12f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_30ed204d-fea3-4702-97b4-2cccfaa85cb8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_99bac6cf-1092-46c9-8d49-27765967a12f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesAvailableforsaleSecuritiesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesAvailableforsaleSecuritiesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesAvailableforsaleSecuritiesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesGrossRealizedGainsandLossesfromSalesorMaturitiesofAvailableforSaleSecuritiesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesGrossRealizedGainsandLossesfromSalesorMaturitiesofAvailableforSaleSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesGrossRealizedGainsandLossesfromSalesorMaturitiesofAvailableforSaleSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_1666d903-8ff2-4ed4-bae0-e3ba9e8cb433" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_992e0d48-89c2-4551-91b5-5eac5b79c17a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_1666d903-8ff2-4ed4-bae0-e3ba9e8cb433" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_992e0d48-89c2-4551-91b5-5eac5b79c17a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_b566f643-d90e-44c0-857d-975925527046" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGain"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_1666d903-8ff2-4ed4-bae0-e3ba9e8cb433" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_b566f643-d90e-44c0-857d-975925527046" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostFairValueandWeightedAverageYieldbyMaturityDateDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesAmortizedCostFairValueandWeightedAverageYieldbyMaturityDateDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesAmortizedCostFairValueandWeightedAverageYieldbyMaturityDateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_9798c52a-4a6a-4672-b80e-d3a3a6b0a407" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_7cf2bb5b-7d73-4e5f-9311-c58af3bceefe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_9798c52a-4a6a-4672-b80e-d3a3a6b0a407" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_7cf2bb5b-7d73-4e5f-9311-c58af3bceefe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_b04c8de4-9f24-4d7f-b7d0-09597d08e142" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_9798c52a-4a6a-4672-b80e-d3a3a6b0a407" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_b04c8de4-9f24-4d7f-b7d0-09597d08e142" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_d6e5dcbc-b762-4741-a47d-27121a37548c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_9798c52a-4a6a-4672-b80e-d3a3a6b0a407" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_d6e5dcbc-b762-4741-a47d-27121a37548c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_31a66e75-598f-45c0-a594-41a4bb79ed5a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_9798c52a-4a6a-4672-b80e-d3a3a6b0a407" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_31a66e75-598f-45c0-a594-41a4bb79ed5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_b964c22b-31a2-431a-826f-2b5275503394" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_f7cb07ce-aa2e-4bca-bd7d-39672a1bbf89" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_b964c22b-31a2-431a-826f-2b5275503394" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_f7cb07ce-aa2e-4bca-bd7d-39672a1bbf89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_6478a31b-e38f-4df2-b200-d197d1a777b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_b964c22b-31a2-431a-826f-2b5275503394" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_6478a31b-e38f-4df2-b200-d197d1a777b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_893120e4-792e-4c66-9ba9-c4b15a6ebcfd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_b964c22b-31a2-431a-826f-2b5275503394" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_893120e4-792e-4c66-9ba9-c4b15a6ebcfd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_49b4d040-c912-4af7-bb2b-cc5573f813c4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_b964c22b-31a2-431a-826f-2b5275503394" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_49b4d040-c912-4af7-bb2b-cc5573f813c4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesGrossUnrealizedLossesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesGrossUnrealizedLossesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesGrossUnrealizedLossesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesGrossUnrealizedLossesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesGrossUnrealizedLossesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesGrossUnrealizedLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_03cfb00c-06d6-4fb0-b991-b35f780c2b15" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions_855df20d-1230-4ff0-b947-5dcaecee445d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_03cfb00c-06d6-4fb0-b991-b35f780c2b15" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions_855df20d-1230-4ff0-b947-5dcaecee445d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_b429fe24-a7cd-4a9b-87a7-c52acbc88932" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionNumberOfPositions_03cfb00c-06d6-4fb0-b991-b35f780c2b15" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_b429fe24-a7cd-4a9b-87a7-c52acbc88932" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_eaca2f48-052f-477e-9478-0558a676cb30" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_17f044fb-0690-4aa2-b6e5-6d73e78f0fe3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_eaca2f48-052f-477e-9478-0558a676cb30" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_17f044fb-0690-4aa2-b6e5-6d73e78f0fe3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_bb237a38-c58b-4319-9985-3498ebf0dcfa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_eaca2f48-052f-477e-9478-0558a676cb30" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_bb237a38-c58b-4319-9985-3498ebf0dcfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_094b62c7-f115-43d5-9f27-fb1f1f6d3773" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_976a3064-3a3f-4d56-a42c-a7dd22722623" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_094b62c7-f115-43d5-9f27-fb1f1f6d3773" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_976a3064-3a3f-4d56-a42c-a7dd22722623" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_1f30b759-32d6-4a13-9142-95f835e7601c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_094b62c7-f115-43d5-9f27-fb1f1f6d3773" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_1f30b759-32d6-4a13-9142-95f835e7601c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesOtherThanTemporaryImpairmentLossesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesOtherThanTemporaryImpairmentLossesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesOtherThanTemporaryImpairmentLossesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesEquitySecuritiesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesEquitySecuritiesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesEquitySecuritiesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SecuritiesEquitySecuritiesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#SecuritiesEquitySecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SecuritiesEquitySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_9f1920b6-7a8d-45ea-8585-c41b60887b72" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_97bc6969-954c-4e27-b8c9-8728ce5ba28e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiRealizedGainLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_9f1920b6-7a8d-45ea-8585-c41b60887b72" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_97bc6969-954c-4e27-b8c9-8728ce5ba28e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_6c8267a9-4d0a-42e0-afe0-d99ce776c086" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_9f1920b6-7a8d-45ea-8585-c41b60887b72" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_6c8267a9-4d0a-42e0-afe0-d99ce776c086" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeases" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeases"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeases" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesCategoriesofLoansDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesCategoriesofLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesCategoriesofLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_d2a24029-eee0-4a0d-a7c4-f688a89cef19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_d639cfae-d05f-4803-b985-254bb4f0f22f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_d2a24029-eee0-4a0d-a7c4-f688a89cef19" xlink:to="loc_us-gaap_NotesReceivableGross_d639cfae-d05f-4803-b985-254bb4f0f22f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_5a3d0b3d-b2ad-4906-b69c-9da2ff238c73" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_d2a24029-eee0-4a0d-a7c4-f688a89cef19" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_5a3d0b3d-b2ad-4906-b69c-9da2ff238c73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableDeferredIncome_60d3c402-17e0-4300-a9bf-0589aace437f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableDeferredIncome"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_d2a24029-eee0-4a0d-a7c4-f688a89cef19" xlink:to="loc_us-gaap_FinancingReceivableDeferredIncome_60d3c402-17e0-4300-a9bf-0589aace437f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesAllowanceforLoanLossesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesAllowanceforLoanLossesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesAllowanceforLoanLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_01fc9264-c683-433e-99c5-1cf3992435a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment_f6c9e1c8-38ad-4049-9243-ce8d10a8af8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_01fc9264-c683-433e-99c5-1cf3992435a6" xlink:to="loc_us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment_f6c9e1c8-38ad-4049-9243-ce8d10a8af8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment_3a78ce36-bc43-46a6-8ca0-d37f19be521c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_01fc9264-c683-433e-99c5-1cf3992435a6" xlink:to="loc_us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment_3a78ce36-bc43-46a6-8ca0-d37f19be521c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesInternalRiskRatingsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesInternalRiskRatingsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesInternalRiskRatingsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesLoanAgingAnalysisDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesLoanAgingAnalysisDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesLoanAgingAnalysisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_e3a0c16e-c0bf-4530-9d92-b2528a1e56b8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDue_e1d71d61-2fb5-4fe4-abda-e01d7ad1ba25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_e3a0c16e-c0bf-4530-9d92-b2528a1e56b8" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDue_e1d71d61-2fb5-4fe4-abda-e01d7ad1ba25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentCurrent_324fd771-10fc-48b8-8609-6c8dd675fd8e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_e3a0c16e-c0bf-4530-9d92-b2528a1e56b8" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentCurrent_324fd771-10fc-48b8-8609-6c8dd675fd8e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesImpairedLoansDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesImpairedLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesImpairedLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_08646131-991b-4f3d-b501-fd050aa80124" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceAverageRecordedInvestment_04862978-4d32-443e-91fb-06d2adfeee9a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceAverageRecordedInvestment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_08646131-991b-4f3d-b501-fd050aa80124" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceAverageRecordedInvestment_04862978-4d32-443e-91fb-06d2adfeee9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceAverageRecordedInvestment_95b12f83-5309-4680-a790-1691c5c5782a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceAverageRecordedInvestment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_08646131-991b-4f3d-b501-fd050aa80124" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceAverageRecordedInvestment_95b12f83-5309-4680-a790-1691c5c5782a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableRecordedInvestment_5a92c25d-d1d9-4738-a1b7-ac0941cf7b4e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableRecordedInvestment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_e41f3dd3-b19d-4fb4-aea7-0d5e3334f7da" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableRecordedInvestment_5a92c25d-d1d9-4738-a1b7-ac0941cf7b4e" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_e41f3dd3-b19d-4fb4-aea7-0d5e3334f7da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_a694037e-353c-4c4e-a9f7-05169a64fd4c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableRecordedInvestment_5a92c25d-d1d9-4738-a1b7-ac0941cf7b4e" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_a694037e-353c-4c4e-a9f7-05169a64fd4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_11b16d27-3869-49ea-a67c-b0ecfa2d8fdf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_4b11e223-7e84-4716-a22c-16f80a51fdc7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_11b16d27-3869-49ea-a67c-b0ecfa2d8fdf" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_4b11e223-7e84-4716-a22c-16f80a51fdc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_22759f1b-4c57-4e7a-8c90-d5d76bf57229" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_11b16d27-3869-49ea-a67c-b0ecfa2d8fdf" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_22759f1b-4c57-4e7a-8c90-d5d76bf57229" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod_2f27d3eb-a8ba-4c90-bb10-6abff05de9a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceInterestIncomeAccrualMethod_1a0eadd5-04bc-42fa-83e8-5efb8127e434" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceInterestIncomeAccrualMethod"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod_2f27d3eb-a8ba-4c90-bb10-6abff05de9a5" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceInterestIncomeAccrualMethod_1a0eadd5-04bc-42fa-83e8-5efb8127e434" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceInterestIncomeAccrualMethod_014b1e44-dad1-4e66-8970-2ad3e2c96531" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceInterestIncomeAccrualMethod"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod_2f27d3eb-a8ba-4c90-bb10-6abff05de9a5" xlink:to="loc_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceInterestIncomeAccrualMethod_014b1e44-dad1-4e66-8970-2ad3e2c96531" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesNonaccrualLoansDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesNonaccrualLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesNonaccrualLoansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesTroubledDebtRestructuringLoansDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#LoansandAllowanceforLoanLeasesTroubledDebtRestructuringLoansDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/LoansandAllowanceforLoanLeasesTroubledDebtRestructuringLoansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/PremisesandEquipment" xlink:type="simple" xlink:href="cfb-20201231.xsd#PremisesandEquipment"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/PremisesandEquipment" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/PremisesandEquipmentTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#PremisesandEquipmentTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/PremisesandEquipmentTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/PremisesandEquipmentMajorClassificationsofPremisesandEquipmentDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#PremisesandEquipmentMajorClassificationsofPremisesandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/PremisesandEquipmentMajorClassificationsofPremisesandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_e50693d2-2231-4c34-bff0-3a10bbcb26e7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_5ffe7ea6-959e-4c09-b5f7-7482e5af735c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_e50693d2-2231-4c34-bff0-3a10bbcb26e7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_5ffe7ea6-959e-4c09-b5f7-7482e5af735c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e1394239-6aba-4785-90be-d05c0e88451e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_e50693d2-2231-4c34-bff0-3a10bbcb26e7" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e1394239-6aba-4785-90be-d05c0e88451e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangible" xlink:type="simple" xlink:href="cfb-20201231.xsd#GoodwillandCoreDepositIntangible"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangible" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#GoodwillandCoreDepositIntangibleTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#GoodwillandCoreDepositIntangibleNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleCarryingBasisandAccumulatedAmortizationDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#GoodwillandCoreDepositIntangibleCarryingBasisandAccumulatedAmortizationDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleCarryingBasisandAccumulatedAmortizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cfb_IntangibleAssetsGrossIncludingGoodwill_06058fea-2f42-4a02-b27b-6e55d510d3e3" xlink:href="cfb-20201231.xsd#cfb_IntangibleAssetsGrossIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_2c14c329-b9b4-4c0b-82d3-4ead880312b5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_IntangibleAssetsGrossIncludingGoodwill_06058fea-2f42-4a02-b27b-6e55d510d3e3" xlink:to="loc_us-gaap_GoodwillGross_2c14c329-b9b4-4c0b-82d3-4ead880312b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_b4a7a0ec-aea2-4497-9452-73f0c867aeb7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_IntangibleAssetsGrossIncludingGoodwill_06058fea-2f42-4a02-b27b-6e55d510d3e3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_b4a7a0ec-aea2-4497-9452-73f0c867aeb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_321aad86-3afc-454d-85ca-02a68dfad47e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_IntangibleAssetsGrossIncludingGoodwill_72447fbf-dbdd-4517-b5d0-4ebd30525dc0" xlink:href="cfb-20201231.xsd#cfb_IntangibleAssetsGrossIncludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_321aad86-3afc-454d-85ca-02a68dfad47e" xlink:to="loc_cfb_IntangibleAssetsGrossIncludingGoodwill_72447fbf-dbdd-4517-b5d0-4ebd30525dc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d042bc62-cb49-48ca-b19f-267a63add4a0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_321aad86-3afc-454d-85ca-02a68dfad47e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d042bc62-cb49-48ca-b19f-267a63add4a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_5e71d19a-4301-433a-a046-49b864093944" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_321aad86-3afc-454d-85ca-02a68dfad47e" xlink:to="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_5e71d19a-4301-433a-a046-49b864093944" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_fbc0dac3-24a3-4ce4-a0f3-99202b7dc540" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_bb6aed72-4c56-44f2-a0d3-b82d255d64b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_fbc0dac3-24a3-4ce4-a0f3-99202b7dc540" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_bb6aed72-4c56-44f2-a0d3-b82d255d64b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_38eece05-8f1a-4e52-a9aa-a73935c9b4c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_fbc0dac3-24a3-4ce4-a0f3-99202b7dc540" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_38eece05-8f1a-4e52-a9aa-a73935c9b4c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_866aab93-1b4b-4fe0-a404-0089c2892332" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_572e9f3d-0203-414e-a8a8-5ec630bf446d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Goodwill_866aab93-1b4b-4fe0-a404-0089c2892332" xlink:to="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_572e9f3d-0203-414e-a8a8-5ec630bf446d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_ff7a7808-a92b-4220-bb7a-7a7ccec6c439" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Goodwill_866aab93-1b4b-4fe0-a404-0089c2892332" xlink:to="loc_us-gaap_GoodwillGross_ff7a7808-a92b-4220-bb7a-7a7ccec6c439" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleCarryingBasisandAccumulatedAmortizationDetails_1" xlink:type="simple" xlink:href="cfb-20201231.xsd#GoodwillandCoreDepositIntangibleCarryingBasisandAccumulatedAmortizationDetails_1"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/GoodwillandCoreDepositIntangibleCarryingBasisandAccumulatedAmortizationDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_d91f2056-b566-4246-8f4b-806d913b5ab1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_8f35325e-2382-49ed-ab95-e9e44a0ca1c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_d91f2056-b566-4246-8f4b-806d913b5ab1" xlink:to="loc_us-gaap_Goodwill_8f35325e-2382-49ed-ab95-e9e44a0ca1c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6b09e423-2997-43a0-afc8-7dc642542d91" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_d91f2056-b566-4246-8f4b-806d913b5ab1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6b09e423-2997-43a0-afc8-7dc642542d91" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingActivities" xlink:type="simple" xlink:href="cfb-20201231.xsd#DerivativesandHedgingActivities"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingActivities" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#DerivativesandHedgingActivitiesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#DerivativesandHedgingActivitiesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesDerivativesNotDesignatedasHedgingInstrumentsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#DerivativesandHedgingActivitiesDerivativesNotDesignatedasHedgingInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesDerivativesNotDesignatedasHedgingInstrumentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesFairValueofDerivativesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#DerivativesandHedgingActivitiesFairValueofDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DerivativesandHedgingActivitiesFairValueofDerivativesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ForeclosedAssets" xlink:type="simple" xlink:href="cfb-20201231.xsd#ForeclosedAssets"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ForeclosedAssets" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/InterestbearingTimeDeposits" xlink:type="simple" xlink:href="cfb-20201231.xsd#InterestbearingTimeDeposits"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/InterestbearingTimeDeposits" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/InterestbearingTimeDepositsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#InterestbearingTimeDepositsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/InterestbearingTimeDepositsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/BorrowingArrangements" xlink:type="simple" xlink:href="cfb-20201231.xsd#BorrowingArrangements"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/BorrowingArrangements" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/BorrowingArrangementsTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#BorrowingArrangementsTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/BorrowingArrangementsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingsSummaryDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#BorrowingArrangementsBorrowingsSummaryDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingsSummaryDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingCapacityDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#BorrowingArrangementsBorrowingCapacityDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingCapacityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingMaturitiesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#BorrowingArrangementsBorrowingMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_24f073cd-7248-44f0-b871-eb25a36c974e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_773ab22d-9129-4df5-ade8-41cf856905bb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_24f073cd-7248-44f0-b871-eb25a36c974e" xlink:to="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_773ab22d-9129-4df5-ade8-41cf856905bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_9bb4b40f-88b3-43a3-9f26-59fb7c7136c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_24f073cd-7248-44f0-b871-eb25a36c974e" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_9bb4b40f-88b3-43a3-9f26-59fb7c7136c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_3c380f3f-a0a1-4740-b4ef-8fee778a95c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_24f073cd-7248-44f0-b871-eb25a36c974e" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_3c380f3f-a0a1-4740-b4ef-8fee778a95c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_c30585a8-6c39-4c88-b10f-17386f234f01" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_24f073cd-7248-44f0-b871-eb25a36c974e" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_c30585a8-6c39-4c88-b10f-17386f234f01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_3a046fc5-e7da-466c-8cb6-07f6378057b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_24f073cd-7248-44f0-b871-eb25a36c974e" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_3a046fc5-e7da-466c-8cb6-07f6378057b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_3b7eb681-35ff-4839-8106-dd255869c2b8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesAfterRollingYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_24f073cd-7248-44f0-b871-eb25a36c974e" xlink:to="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_3b7eb681-35ff-4839-8106-dd255869c2b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowings_7b22a1dd-418a-41b8-bf59-213348f6fa26" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowings"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_90333f84-23df-46fe-9d8c-8783f3acfeca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_7b22a1dd-418a-41b8-bf59-213348f6fa26" xlink:to="loc_us-gaap_TimeDeposits_90333f84-23df-46fe-9d8c-8783f3acfeca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_feed8cfe-be42-444c-a188-60302f57bfa3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_7b22a1dd-418a-41b8-bf59-213348f6fa26" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_feed8cfe-be42-444c-a188-60302f57bfa3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_5896b308-449e-485d-b7d7-655f7c6df5bd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_7b22a1dd-418a-41b8-bf59-213348f6fa26" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_5896b308-449e-485d-b7d7-655f7c6df5bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_ac429ab2-4446-4187-bd4c-38b63460b1c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_7b22a1dd-418a-41b8-bf59-213348f6fa26" xlink:to="loc_us-gaap_LongTermDebt_ac429ab2-4446-4187-bd4c-38b63460b1c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_e4d170eb-dd2f-4b9a-bcba-205bc430084e" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_201b527c-3e52-4157-a09d-96280a409e66" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_e4d170eb-dd2f-4b9a-bcba-205bc430084e" xlink:to="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_201b527c-3e52-4157-a09d-96280a409e66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_7c730d89-91a8-4439-864d-5633f7713c3d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_e4d170eb-dd2f-4b9a-bcba-205bc430084e" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_7c730d89-91a8-4439-864d-5633f7713c3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_a0fe2a8f-f527-4906-bc5e-c85161b8ead9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_e4d170eb-dd2f-4b9a-bcba-205bc430084e" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_a0fe2a8f-f527-4906-bc5e-c85161b8ead9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_f818bdde-5c10-4595-a791-2d69b1709e72" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_e4d170eb-dd2f-4b9a-bcba-205bc430084e" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_f818bdde-5c10-4595-a791-2d69b1709e72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_51747788-b1dd-464b-b863-7665cff88f95" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_9d4557ee-3da3-451a-a135-dca6a9c0e17b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_51747788-b1dd-464b-b863-7665cff88f95" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearTwo_9d4557ee-3da3-451a-a135-dca6a9c0e17b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_36f95d90-1a13-4037-b3a8-0ecebd77e458" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_51747788-b1dd-464b-b863-7665cff88f95" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_36f95d90-1a13-4037-b3a8-0ecebd77e458" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_17fed538-44bd-48c4-a362-eabc899e2d1d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_51747788-b1dd-464b-b863-7665cff88f95" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_17fed538-44bd-48c4-a362-eabc899e2d1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_6cfeb044-e91a-43f4-85e6-5da0d75d28d9" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_2428500d-d274-4b7c-b246-a2d1e059fa80" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_6cfeb044-e91a-43f4-85e6-5da0d75d28d9" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearThree_2428500d-d274-4b7c-b246-a2d1e059fa80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_14405405-af37-468d-a8f1-dce8023aa00e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_6cfeb044-e91a-43f4-85e6-5da0d75d28d9" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_14405405-af37-468d-a8f1-dce8023aa00e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_437aafb7-b5d2-4d18-bbf9-6d1c792b7ba0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_6cfeb044-e91a-43f4-85e6-5da0d75d28d9" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_437aafb7-b5d2-4d18-bbf9-6d1c792b7ba0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_1597f809-fca8-4da0-b7b3-953c75e90419" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_a9e54e00-2a8d-427c-8d00-8d9c685834b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_1597f809-fca8-4da0-b7b3-953c75e90419" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInNextRollingTwelveMonths_a9e54e00-2a8d-427c-8d00-8d9c685834b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_2963c4a9-dfbb-4e72-a8d1-303efe62ab7f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_1597f809-fca8-4da0-b7b3-953c75e90419" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearTwo_2963c4a9-dfbb-4e72-a8d1-303efe62ab7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_34ca958a-87ad-48ee-bcf1-09462391292c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_1597f809-fca8-4da0-b7b3-953c75e90419" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearThree_34ca958a-87ad-48ee-bcf1-09462391292c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_1efcd134-c7c4-4998-968d-ac30e033defb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_1597f809-fca8-4da0-b7b3-953c75e90419" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_1efcd134-c7c4-4998-968d-ac30e033defb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_3766acf4-56c5-4c95-880f-218b676be4b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_1597f809-fca8-4da0-b7b3-953c75e90419" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_3766acf4-56c5-4c95-880f-218b676be4b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_c95ef388-7bea-484a-b177-8f2c5a6a19e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_1597f809-fca8-4da0-b7b3-953c75e90419" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_c95ef388-7bea-484a-b177-8f2c5a6a19e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_71b24e42-6f13-42a3-a227-d4f8a7678208" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_2603ed01-cb0f-4d6f-868a-d26c3435f1ad" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_71b24e42-6f13-42a3-a227-d4f8a7678208" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFour_2603ed01-cb0f-4d6f-868a-d26c3435f1ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_ac9fccbe-cdbf-4ba8-ac37-6e90f88e113a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_71b24e42-6f13-42a3-a227-d4f8a7678208" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFour_ac9fccbe-cdbf-4ba8-ac37-6e90f88e113a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_d396dfd3-ddfb-49e2-b0c1-6a36236a4417" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_71b24e42-6f13-42a3-a227-d4f8a7678208" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_d396dfd3-ddfb-49e2-b0c1-6a36236a4417" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_9ceb4056-30ad-456b-8dae-02c210030f60" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_02a93eb1-54b6-4dd8-8d46-584e8044f42b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_9ceb4056-30ad-456b-8dae-02c210030f60" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextRollingTwelveMonths_02a93eb1-54b6-4dd8-8d46-584e8044f42b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_e49d5e6c-bf54-4010-a2d3-f40914aaf6b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_9ceb4056-30ad-456b-8dae-02c210030f60" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearTwo_e49d5e6c-bf54-4010-a2d3-f40914aaf6b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_857f44d5-8da9-4b4f-b098-e73159c8203b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_9ceb4056-30ad-456b-8dae-02c210030f60" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearThree_857f44d5-8da9-4b4f-b098-e73159c8203b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_5c84e690-43da-4548-b147-24bdd00fc57a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_9ceb4056-30ad-456b-8dae-02c210030f60" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFour_5c84e690-43da-4548-b147-24bdd00fc57a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_5135cd64-5e45-49f4-885f-f25bebf0f687" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_9ceb4056-30ad-456b-8dae-02c210030f60" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_5135cd64-5e45-49f4-885f-f25bebf0f687" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_c2b66844-7f99-4e87-a7d1-0ef70235f352" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_9ceb4056-30ad-456b-8dae-02c210030f60" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_c2b66844-7f99-4e87-a7d1-0ef70235f352" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_b098d8db-1008-44fb-8f4d-26967c578f40" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_0bdd82c2-d48b-42c2-bc46-4c0cf3d9b3c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesRollingYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_b098d8db-1008-44fb-8f4d-26967c578f40" xlink:to="loc_us-gaap_TimeDepositMaturitiesRollingYearFive_0bdd82c2-d48b-42c2-bc46-4c0cf3d9b3c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_379ab9e2-a0c9-478e-a90d-a304b5477d72" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_b098d8db-1008-44fb-8f4d-26967c578f40" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueInRollingYearFive_379ab9e2-a0c9-478e-a90d-a304b5477d72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_4354a2b8-4ea3-4d20-839e-4cfde543e48c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_b098d8db-1008-44fb-8f4d-26967c578f40" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingYearFive_4354a2b8-4ea3-4d20-839e-4cfde543e48c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_202c7226-6d46-494a-9f21-321e726c2e02" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_9cbaa91d-35dc-4f0c-b748-98d5e3a290dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TimeDepositMaturitiesAfterRollingYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_202c7226-6d46-494a-9f21-321e726c2e02" xlink:to="loc_us-gaap_TimeDepositMaturitiesAfterRollingYearFive_9cbaa91d-35dc-4f0c-b748-98d5e3a290dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_dce67702-eb7d-4b82-821f-ee00b208049c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_202c7226-6d46-494a-9f21-321e726c2e02" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueAfterRollingYearFive_dce67702-eb7d-4b82-821f-ee00b208049c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_e152d80d-e4fc-4449-8354-ffdc4bcada6b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_202c7226-6d46-494a-9f21-321e726c2e02" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInRollingAfterYearFive_e152d80d-e4fc-4449-8354-ffdc4bcada6b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingMaturitiesDetails_1" xlink:type="simple" xlink:href="cfb-20201231.xsd#BorrowingArrangementsBorrowingMaturitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/BorrowingArrangementsBorrowingMaturitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowings_6196cdaf-a2a9-49d2-bb72-2f933a49ac7e" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowings"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_ec9e7180-6792-4c4a-b2c6-ca513c0b0c22" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_6196cdaf-a2a9-49d2-bb72-2f933a49ac7e" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsNextRollingTwelveMonths_ec9e7180-6792-4c4a-b2c6-ca513c0b0c22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_d9004f86-de9a-40c7-afb7-0f95d6f64105" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_6196cdaf-a2a9-49d2-bb72-2f933a49ac7e" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearTwo_d9004f86-de9a-40c7-afb7-0f95d6f64105" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_d2d4a5db-8e89-4ee2-8cc4-cfac7b08235c" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_6196cdaf-a2a9-49d2-bb72-2f933a49ac7e" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearThree_d2d4a5db-8e89-4ee2-8cc4-cfac7b08235c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_d67b3dd4-1e9e-48ab-af1d-413050614f6b" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_6196cdaf-a2a9-49d2-bb72-2f933a49ac7e" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFour_d67b3dd4-1e9e-48ab-af1d-413050614f6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_4a30ff94-0ba6-4414-b495-86da0611f7c8" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_6196cdaf-a2a9-49d2-bb72-2f933a49ac7e" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsRollingYearFive_4a30ff94-0ba6-4414-b495-86da0611f7c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_cd83c44b-9c27-4c19-b53a-0be99e7682fd" xlink:href="cfb-20201231.xsd#cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cfb_TimeDepositMaturitiesAndBorrowings_6196cdaf-a2a9-49d2-bb72-2f933a49ac7e" xlink:to="loc_cfb_TimeDepositMaturitiesAndBorrowingsAfterRollingYearFive_cd83c44b-9c27-4c19-b53a-0be99e7682fd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxes" xlink:type="simple" xlink:href="cfb-20201231.xsd#IncomeTaxes"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxes" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#IncomeTaxesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxesProvisionforIncomeTaxesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#IncomeTaxesProvisionforIncomeTaxesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxesProvisionforIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_56647bc4-db96-4774-a703-e32018e0c909" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_43cbc6d9-b6ae-4916-8eab-2fd1d4231d55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_56647bc4-db96-4774-a703-e32018e0c909" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_43cbc6d9-b6ae-4916-8eab-2fd1d4231d55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_f6e2f00e-9986-4e3d-b1cc-4e05fe74b881" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_56647bc4-db96-4774-a703-e32018e0c909" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_f6e2f00e-9986-4e3d-b1cc-4e05fe74b881" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxesEffectiveIncomeTaxReconciliationDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#IncomeTaxesEffectiveIncomeTaxReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxesEffectiveIncomeTaxReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_d69c04e8-14e2-43b0-a120-0171cb579187" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_d69c04e8-14e2-43b0-a120-0171cb579187" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxExemptIncome_0b9e5eae-5413-4276-a6d2-2cbb13335e7a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxExemptIncome"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxExemptIncome_0b9e5eae-5413-4276-a6d2-2cbb13335e7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_a3c39753-20b9-4521-9627-d37a33586f87" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_a3c39753-20b9-4521-9627-d37a33586f87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCredits_92782495-f31f-46cb-a1bc-f0a8c1f2ed9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCredits"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCredits_92782495-f31f-46cb-a1bc-f0a8c1f2ed9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_7da41aa0-d575-4754-b787-0df8512b0934" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_7da41aa0-d575-4754-b787-0df8512b0934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_391481b4-0461-4018-a981-906f90c0e470" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_391481b4-0461-4018-a981-906f90c0e470" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_5b381510-08bf-4cb8-9f4e-61a42ff2736c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_5b381510-08bf-4cb8-9f4e-61a42ff2736c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses_8a23e9cb-4621-46ef-95df-02c53cbda040" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_701537f1-5e38-4e91-9112-fd6f1bf260e7" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseImpairmentLosses_8a23e9cb-4621-46ef-95df-02c53cbda040" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#IncomeTaxesDeferredTaxesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_a4559e9a-18e5-40be-8968-e2f6fc8a6797" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_8ef3e257-7b66-4a85-be4b-c5823e075418" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_a4559e9a-18e5-40be-8968-e2f6fc8a6797" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_8ef3e257-7b66-4a85-be4b-c5823e075418" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_8981085e-9bd1-41af-8ca7-742472f6145a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_a4559e9a-18e5-40be-8968-e2f6fc8a6797" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_8981085e-9bd1-41af-8ca7-742472f6145a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_29befe76-3996-4c44-983b-c73509320ef5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxLiabilitiesUnrealizedGainsOnAvailableForSaleSecurities_103f2ba8-25a5-41b4-bbc3-abe64b455e3f" xlink:href="cfb-20201231.xsd#cfb_DeferredTaxLiabilitiesUnrealizedGainsOnAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_29befe76-3996-4c44-983b-c73509320ef5" xlink:to="loc_cfb_DeferredTaxLiabilitiesUnrealizedGainsOnAvailableForSaleSecurities_103f2ba8-25a5-41b4-bbc3-abe64b455e3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxLiabilitiesFederalHomeLoanBankBasis_a874495b-8415-4f5a-9228-9980c76e7195" xlink:href="cfb-20201231.xsd#cfb_DeferredTaxLiabilitiesFederalHomeLoanBankBasis"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_29befe76-3996-4c44-983b-c73509320ef5" xlink:to="loc_cfb_DeferredTaxLiabilitiesFederalHomeLoanBankBasis_a874495b-8415-4f5a-9228-9980c76e7195" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_ec69ef0e-a4d6-41ed-8ab2-dc570c69035f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_29befe76-3996-4c44-983b-c73509320ef5" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_ec69ef0e-a4d6-41ed-8ab2-dc570c69035f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_36ae9e21-bbc9-433f-af27-eb6b3f08eae1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_29befe76-3996-4c44-983b-c73509320ef5" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_36ae9e21-bbc9-433f-af27-eb6b3f08eae1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_5d96c917-d13c-4e80-b3ac-cc496f52cce5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_5d96c917-d13c-4e80-b3ac-cc496f52cce5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxAssetsLeaseIncentive_7cbdd221-f073-4a86-bb2b-4203e96d6fe4" xlink:href="cfb-20201231.xsd#cfb_DeferredTaxAssetsLeaseIncentive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_cfb_DeferredTaxAssetsLeaseIncentive_7cbdd221-f073-4a86-bb2b-4203e96d6fe4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsImpairmentLosses_1a1b219a-2645-4f06-916f-14208fceeb20" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsImpairmentLosses"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsImpairmentLosses_1a1b219a-2645-4f06-916f-14208fceeb20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DeferredTaxAssetsLoanFees_1a9edd3e-0ff7-4175-b1c4-697fab6367f4" xlink:href="cfb-20201231.xsd#cfb_DeferredTaxAssetsLoanFees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_cfb_DeferredTaxAssetsLoanFees_1a9edd3e-0ff7-4175-b1c4-697fab6367f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_49dbe745-8d24-4b73-a4cc-768a9c641b69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_49dbe745-8d24-4b73-a4cc-768a9c641b69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_7017d992-9374-48b2-8c34-07352c736911" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_7017d992-9374-48b2-8c34-07352c736911" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsStateTaxes_fa266b00-f07d-471e-89e0-72246bd118c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsStateTaxes"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_us-gaap_DeferredTaxAssetsStateTaxes_fa266b00-f07d-471e-89e0-72246bd118c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_9ad6227d-c23e-446b-8926-e7e7caaa6659" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_bf5f29f0-de54-40cb-bed0-95fde0ef4123" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_9ad6227d-c23e-446b-8926-e7e7caaa6659" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ChangesinAccumulatedOtherComprehensiveIncome" xlink:type="simple" xlink:href="cfb-20201231.xsd#ChangesinAccumulatedOtherComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ChangesinAccumulatedOtherComprehensiveIncome" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ChangesinAccumulatedOtherComprehensiveIncomeTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#ChangesinAccumulatedOtherComprehensiveIncomeTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ChangesinAccumulatedOtherComprehensiveIncomeTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ChangesinAccumulatedOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#ChangesinAccumulatedOtherComprehensiveIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ChangesinAccumulatedOtherComprehensiveIncomeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RegulatoryMatters" xlink:type="simple" xlink:href="cfb-20201231.xsd#RegulatoryMatters"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RegulatoryMatters" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RegulatoryMattersTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#RegulatoryMattersTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RegulatoryMattersTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RegulatoryMattersDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#RegulatoryMattersDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RegulatoryMattersDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EmployeeBenefitPlan" xlink:type="simple" xlink:href="cfb-20201231.xsd#EmployeeBenefitPlan"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EmployeeBenefitPlan" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/EmployeeBenefitPlanDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#EmployeeBenefitPlanDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/EmployeeBenefitPlanDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RevenuefromContractswithCustomers" xlink:type="simple" xlink:href="cfb-20201231.xsd#RevenuefromContractswithCustomers"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RevenuefromContractswithCustomers" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RevenuefromContractswithCustomersTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#RevenuefromContractswithCustomersTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RevenuefromContractswithCustomersTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/RevenuefromContractswithCustomersDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#RevenuefromContractswithCustomersDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/RevenuefromContractswithCustomersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_147dd0b0-4a2f-4b4e-9df2-4627edc3facd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2bee7ba3-56c8-4ca9-892e-b4191a803ed9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_147dd0b0-4a2f-4b4e-9df2-4627edc3facd" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2bee7ba3-56c8-4ca9-892e-b4191a803ed9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomerExcludingInterestIncome_175c57ff-55f2-4cf2-b58a-b57e723a47ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueNotFromContractWithCustomerExcludingInterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_147dd0b0-4a2f-4b4e-9df2-4627edc3facd" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomerExcludingInterestIncome_175c57ff-55f2-4cf2-b58a-b57e723a47ee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensation"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensation" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationStockBasedCompensationDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationStockBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationStockBasedCompensationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationSSARsAssumptionsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationSSARsAssumptionsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationSSARsAssumptionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationSSARsActivityDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationSSARsActivityDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationSSARsActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationPerformanceBasedAwardsActivityDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationPerformanceBasedAwardsActivityDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationPerformanceBasedAwardsActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationRSUsandRSAsActivityDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationRSUsandRSAsActivityDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationRSUsandRSAsActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationESPPAssumptionsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationESPPAssumptionsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationESPPAssumptionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockBasedCompensationEventsandtheImpacttoEquityBasedCompensationDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockBasedCompensationEventsandtheImpacttoEquityBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockBasedCompensationEventsandtheImpacttoEquityBasedCompensationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockWarrants" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockWarrants"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockWarrants" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockWarrantsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockWarrantsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockWarrantsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/OperatingLeases" xlink:type="simple" xlink:href="cfb-20201231.xsd#OperatingLeases"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/OperatingLeases" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/OperatingLeasesTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#OperatingLeasesTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/OperatingLeasesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/OperatingLeasesNarrativeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#OperatingLeasesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/OperatingLeasesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/OperatingLeasesRentalExpenseDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#OperatingLeasesRentalExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/OperatingLeasesRentalExpenseDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/OperatingLeasesFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#OperatingLeasesFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/OperatingLeasesFutureMinimumLeasePaymentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstruments" xlink:type="simple" xlink:href="cfb-20201231.xsd#DisclosureaboutFairValueofFinancialInstruments"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstruments" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#DisclosuresaboutFairValueofFinancialInstrumentsTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosuresaboutFairValueofFinancialInstrumentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstrumentsNonrecurringMeasurementsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#DisclosureaboutFairValueofFinancialInstrumentsNonrecurringMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstrumentsNonrecurringMeasurementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstrumentsUnobservableInputsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#DisclosureaboutFairValueofFinancialInstrumentsUnobservableInputsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstrumentsUnobservableInputsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstrumentsEstimatedFairValueofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#DisclosureaboutFairValueofFinancialInstrumentsEstimatedFairValueofFinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/DisclosureaboutFairValueofFinancialInstrumentsEstimatedFairValueofFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_1c5e4770-fb83-4802-9b39-63c923ef43fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsFairValueDisclosure_9b792609-33c5-469c-9359-8f97337eac2e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepositsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_1c5e4770-fb83-4802-9b39-63c923ef43fe" xlink:to="loc_us-gaap_DepositsFairValueDisclosure_9b792609-33c5-469c-9359-8f97337eac2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_f500596a-47cd-4cb1-9c8b-ffcd7e994ef8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_1c5e4770-fb83-4802-9b39-63c923ef43fe" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_f500596a-47cd-4cb1-9c8b-ffcd7e994ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure_ed76abec-69cc-478e-b78b-375beb90039d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_1c5e4770-fb83-4802-9b39-63c923ef43fe" xlink:to="loc_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure_ed76abec-69cc-478e-b78b-375beb90039d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_OtherBorrowingsFairValueDisclosure_db4c3fdc-b956-4c83-bcdb-b1e91c985cc4" xlink:href="cfb-20201231.xsd#cfb_OtherBorrowingsFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_1c5e4770-fb83-4802-9b39-63c923ef43fe" xlink:to="loc_cfb_OtherBorrowingsFairValueDisclosure_db4c3fdc-b956-4c83-bcdb-b1e91c985cc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_InterestPayableFairValueDisclosure_16e80166-5ed8-426a-92ab-6463d068dc89" xlink:href="cfb-20201231.xsd#cfb_InterestPayableFairValueDisclosure"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_1c5e4770-fb83-4802-9b39-63c923ef43fe" xlink:to="loc_cfb_InterestPayableFairValueDisclosure_16e80166-5ed8-426a-92ab-6463d068dc89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_417023df-7e54-45f6-aa11-17742d892258" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_1c5e4770-fb83-4802-9b39-63c923ef43fe" xlink:to="loc_us-gaap_DerivativeLiabilities_417023df-7e54-45f6-aa11-17742d892258" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_d7634646-a410-44a7-99ee-d120aada0cb9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_d7634646-a410-44a7-99ee-d120aada0cb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI_647f9a34-aa65-433e-ab2f-2de1efe22288" xlink:href="cfb-20201231.xsd#cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:to="loc_cfb_DebtSecuritiesAvailableForSaleAndEquitySecuritiesFVNI_647f9a34-aa65-433e-ab2f-2de1efe22288" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_7780003e-acea-4e07-9d95-3b5524293f8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_7780003e-acea-4e07-9d95-3b5524293f8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRestricted_f160fdc1-b003-4678-a582-f8f5ce2af4f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNiRestricted"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRestricted_f160fdc1-b003-4678-a582-f8f5ce2af4f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_InterestReceivableFairValueDisclosure_80780990-dd00-40d3-9385-115e65e1db39" xlink:href="cfb-20201231.xsd#cfb_InterestReceivableFairValueDisclosure"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:to="loc_cfb_InterestReceivableFairValueDisclosure_80780990-dd00-40d3-9385-115e65e1db39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_44eacb04-3e2d-485e-934f-37f720a69286" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:to="loc_us-gaap_DerivativeAssets_44eacb04-3e2d-485e-934f-37f720a69286" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_2dcdc0e3-4d54-40ca-bdc5-99737e46b1b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_0543f21c-0687-4fe4-abc5-0c0bcd3de407" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_2dcdc0e3-4d54-40ca-bdc5-99737e46b1b7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SignificantEstimatesandConcentrations" xlink:type="simple" xlink:href="cfb-20201231.xsd#SignificantEstimatesandConcentrations"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SignificantEstimatesandConcentrations" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CommitmentsandCreditRisk" xlink:type="simple" xlink:href="cfb-20201231.xsd#CommitmentsandCreditRisk"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CommitmentsandCreditRisk" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#CommitmentsandCreditRiskTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#CommitmentsandCreditRiskDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/CommitmentsandCreditRiskDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StockOfferingsandRepurchases" xlink:type="simple" xlink:href="cfb-20201231.xsd#StockOfferingsandRepurchases"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StockOfferingsandRepurchases" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/StocksOfferingsandRepurchasesDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#StocksOfferingsandRepurchasesDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/StocksOfferingsandRepurchasesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatements" xlink:type="simple" xlink:href="cfb-20201231.xsd#ParentCompanyCondensedFinancialStatements"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatements" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsTables" xlink:type="simple" xlink:href="cfb-20201231.xsd#ParentCompanyCondensedFinancialStatementsTables"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsCondensedBalanceSheetDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#ParentCompanyCondensedFinancialStatementsCondensedBalanceSheetDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsCondensedBalanceSheetDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsCondensedStatementsofIncomeDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#ParentCompanyCondensedFinancialStatementsCondensedStatementsofIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsCondensedStatementsofIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_9633bcc5-6965-4c1d-8d69-39057ab125e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromSubsidiariesBeforeTax_a46e781b-7634-42cf-9533-533c1616b6a7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromSubsidiariesBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_9633bcc5-6965-4c1d-8d69-39057ab125e4" xlink:to="loc_us-gaap_IncomeLossFromSubsidiariesBeforeTax_a46e781b-7634-42cf-9533-533c1616b6a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cfb_ManagementFeeIncome_0f78aa15-3d83-4b44-94cc-ee96bfa7a63f" xlink:href="cfb-20201231.xsd#cfb_ManagementFeeIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_9633bcc5-6965-4c1d-8d69-39057ab125e4" xlink:to="loc_cfb_ManagementFeeIncome_0f78aa15-3d83-4b44-94cc-ee96bfa7a63f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_56110e11-03d3-472e-b9de-6d98056ae5a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_9633bcc5-6965-4c1d-8d69-39057ab125e4" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_56110e11-03d3-472e-b9de-6d98056ae5a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_ff2c1470-ff14-4f81-9301-8046d92bbf76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_232d6b75-6a22-4a18-9405-76421c701c85" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_ff2c1470-ff14-4f81-9301-8046d92bbf76" xlink:to="loc_us-gaap_LaborAndRelatedExpense_232d6b75-6a22-4a18-9405-76421c701c85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_853df4a0-ab38-4332-992f-a331c663dee2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_ff2c1470-ff14-4f81-9301-8046d92bbf76" xlink:to="loc_us-gaap_OccupancyNet_853df4a0-ab38-4332-992f-a331c663dee2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_669ca6be-c810-4284-bd17-2b28c6036872" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_ff2c1470-ff14-4f81-9301-8046d92bbf76" xlink:to="loc_us-gaap_OtherNoninterestExpense_669ca6be-c810-4284-bd17-2b28c6036872" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c22014c4-e5f0-4959-800f-468deb0206e8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_5455318e-8969-459f-914c-3c2a93650a03" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_c22014c4-e5f0-4959-800f-468deb0206e8" xlink:to="loc_us-gaap_Revenues_5455318e-8969-459f-914c-3c2a93650a03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_77199594-b7f3-45d7-ac9a-c78cbb95a370" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_c22014c4-e5f0-4959-800f-468deb0206e8" xlink:to="loc_us-gaap_CostsAndExpenses_77199594-b7f3-45d7-ac9a-c78cbb95a370" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8882562e-b93e-4f76-8ba3-a8201044064d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_c22014c4-e5f0-4959-800f-468deb0206e8" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8882562e-b93e-4f76-8ba3-a8201044064d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsCondensedStatementsofCashFlowsDetails" xlink:type="simple" xlink:href="cfb-20201231.xsd#ParentCompanyCondensedFinancialStatementsCondensedStatementsofCashFlowsDetails"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/ParentCompanyCondensedFinancialStatementsCondensedStatementsofCashFlowsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.crossfirstbank.com/role/SubsequentEvents" xlink:type="simple" xlink:href="cfb-20201231.xsd#SubsequentEvents"/>
  <link:calculationLink xlink:role="http://www.crossfirstbank.com/role/SubsequentEvents" xlink:type="extended"/>
</link:linkbase>
